U54 MH084659/MH/NIMH NIH HHS/United States[Grants and Funding] - Search Results

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Subject: U54 MH084659/MH/NIMH NIH HHS/United States[Grants - PubMed

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Results by year

Year	Number of Results
2008	2
2009	10
2010	11
2011	22
2012	32
2013	30
2014	21
2015	21
2016	10
2017	9
2018	2
2019	3
2020	2
2021	1
2022	1
2024	0

152 results

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Effects of acute and repeated administration of the selective M₄ PAM VU0152099 on cocaine versus food choice in male rats.

Thomsen M, Crittenden JR, Lindsley CW, Graybiel AM. Thomsen M, et al. Addict Biol. 2022 Mar;27(2):e13145. doi: 10.1111/adb.13145. Addict Biol. 2022. PMID: 35229940 Free PMC article.

Discovery of structurally distinct tricyclic M₄ positive allosteric modulator (PAM) chemotypes - Part 2.

Long MF, Capstick RA, Spearing PK, Engers JL, Gregro AR, Bollinger SR, Chang S, Luscombe VB, Rodriguez AL, Cho HP, Niswender CM, Bridges TM, Conn PJ, Lindsley CW, Engers DW, Temple KJ. Long MF, et al. Bioorg Med Chem Lett. 2021 Dec 1;53:128416. doi: 10.1016/j.bmcl.2021.128416. Epub 2021 Oct 26. Bioorg Med Chem Lett. 2021. PMID: 34710625 Free PMC article.

Discovery of structurally distinct tricyclic M₄ positive allosteric modulator (PAM) chemotypes.

Temple KJ, Long MF, Engers JL, Watson KJ, Chang S, Luscombe VB, Rodriguez AL, Niswender CM, Bridges TM, Conn PJ, Engers DW, Lindsley CW. Temple KJ, et al. Bioorg Med Chem Lett. 2020 Feb 15;30(4):126811. doi: 10.1016/j.bmcl.2019.126811. Epub 2019 Nov 11. Bioorg Med Chem Lett. 2020. PMID: 31787491

Discovery of a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide M₄ positive allosteric modulator (PAM) chemotype.

Temple KJ, Engers JL, Long MF, Watson KJ, Chang S, Luscombe VB, Jenkins MT, Rodriguez AL, Niswender CM, Bridges TM, Conn PJ, Engers DW, Lindsley CW. Temple KJ, et al. Bioorg Med Chem Lett. 2020 Feb 1;30(3):126812. doi: 10.1016/j.bmcl.2019.126812. Epub 2019 Nov 13. Bioorg Med Chem Lett. 2020. PMID: 31784320

Discovery of a novel 3,4-dimethylcinnoline carboxamide M₄ positive allosteric modulator (PAM) chemotype via scaffold hopping.

Temple KJ, Engers JL, Long MF, Gregro AR, Watson KJ, Chang S, Jenkins MT, Luscombe VB, Rodriguez AL, Niswender CM, Bridges TM, Conn PJ, Engers DW, Lindsley CW. Temple KJ, et al. Bioorg Med Chem Lett. 2019 Nov 1;29(21):126678. doi: 10.1016/j.bmcl.2019.126678. Epub 2019 Sep 10. Bioorg Med Chem Lett. 2019. PMID: 31537424

Total RNA Sequencing of Rett Syndrome Autopsy Samples Identifies the M₄ Muscarinic Receptor as a Novel Therapeutic Target.

Gogliotti RG, Fisher NM, Stansley BJ, Jones CK, Lindsley CW, Conn PJ, Niswender CM. Gogliotti RG, et al. J Pharmacol Exp Ther. 2018 May;365(2):291-300. doi: 10.1124/jpet.117.246991. Epub 2018 Mar 9. J Pharmacol Exp Ther. 2018. PMID: 29523700 Free PMC article.

Effects of muscarinic M₁ and M₄ acetylcholine receptor stimulation on extinction and reinstatement of cocaine seeking in male mice, independent of extinction learning.

Stoll K, Hart R, Lindsley CW, Thomsen M. Stoll K, et al. Psychopharmacology (Berl). 2018 Mar;235(3):815-827. doi: 10.1007/s00213-017-4797-0. Epub 2017 Dec 18. Psychopharmacology (Berl). 2018. PMID: 29250738 Free PMC article.

Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M₄ positive allosteric modulator (PAM) chemotype via scaffold hopping.

Long MF, Engers JL, Chang S, Zhan X, Weiner RL, Luscombe VB, Rodriguez AL, Cho HP, Niswender CM, Bridges TM, Conn PJ, Engers DW, Lindsley CW. Long MF, et al. Bioorg Med Chem Lett. 2017 Nov 15;27(22):4999-5001. doi: 10.1016/j.bmcl.2017.10.016. Epub 2017 Oct 9. Bioorg Med Chem Lett. 2017. PMID: 29037946 Free PMC article.

mGlu₇ potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome.

Gogliotti RG, Senter RK, Fisher NM, Adams J, Zamorano R, Walker AG, Blobaum AL, Engers DW, Hopkins CR, Daniels JS, Jones CK, Lindsley CW, Xiang Z, Conn PJ, Niswender CM. Gogliotti RG, et al. Sci Transl Med. 2017 Aug 16;9(403):eaai7459. doi: 10.1126/scitranslmed.aai7459. Sci Transl Med. 2017. PMID: 28814546 Free PMC article.

Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists.

Bender AM, Weiner RL, Luscombe VB, Ajmera S, Cho HP, Chang S, Zhan X, Rodriguez AL, Niswender CM, Engers DW, Bridges TM, Conn PJ, Lindsley CW. Bender AM, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3576-3581. doi: 10.1016/j.bmcl.2017.05.042. Epub 2017 May 15. Bioorg Med Chem Lett. 2017. PMID: 28633897 Free PMC article.

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