U19 MH085193/MH/NIMH NIH HHS/United States[Grants and Funding] - Search Results

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Subject: U19 MH085193/MH/NIMH NIH HHS/United States[Grants - PubMed

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Year	Number of Results
2010	1
2011	3
2012	6
2013	4
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2015	1
2016	2
2024	0

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Synthesis and biological evaluation of novel hybrids of highly potent and selective α4β2-Nicotinic acetylcholine receptor (nAChR) partial agonists.

Zhang HK, Eaton JB, Fedolak A, Gunosewoyo H, Onajole OK, Brunner D, Lukas RJ, Yu LF, Kozikowski AP. Zhang HK, et al. Eur J Med Chem. 2016 Nov 29;124:689-697. doi: 10.1016/j.ejmech.2016.09.016. Epub 2016 Sep 9. Eur J Med Chem. 2016. PMID: 27639361 Free PMC article.

Synthesis and Behavioral Studies of Chiral Cyclopropanes as Selective α4β2-Nicotinic Acetylcholine Receptor Partial Agonists Exhibiting an Antidepressant Profile. Part III.

Onajole OK, Vallerini GP, Eaton JB, Lukas RJ, Brunner D, Caldarone BJ, Kozikowski AP. Onajole OK, et al. ACS Chem Neurosci. 2016 Jun 15;7(6):811-22. doi: 10.1021/acschemneuro.6b00050. Epub 2016 Apr 21. ACS Chem Neurosci. 2016. PMID: 27035276

Roles of nicotinic acetylcholine receptor β subunit cytoplasmic loops in acute desensitization and single-channel features.

Liu Q, Kuo YP, Shen J, Lukas RJ, Wu J. Liu Q, et al. Neuroscience. 2015 Mar 19;289:315-23. doi: 10.1016/j.neuroscience.2014.12.016. Epub 2014 Dec 20. Neuroscience. 2015. PMID: 25536046 Free PMC article.

Recent developments in novel antidepressants targeting α4β2-nicotinic acetylcholine receptors.

Yu LF, Zhang HK, Caldarone BJ, Eaton JB, Lukas RJ, Kozikowski AP. Yu LF, et al. J Med Chem. 2014 Oct 23;57(20):8204-23. doi: 10.1021/jm401937a. Epub 2014 Jul 2. J Med Chem. 2014. PMID: 24901260 Free PMC article. Review.

The unique α4+/-α4 agonist binding site in (α4)3(β2)2 subtype nicotinic acetylcholine receptors permits differential agonist desensitization pharmacology versus the (α4)2(β2)3 subtype.

Eaton JB, Lucero LM, Stratton H, Chang Y, Cooper JF, Lindstrom JM, Lukas RJ, Whiteaker P. Eaton JB, et al. J Pharmacol Exp Ther. 2014 Jan;348(1):46-58. doi: 10.1124/jpet.113.208389. Epub 2013 Nov 4. J Pharmacol Exp Ther. 2014. PMID: 24190916 Free PMC article.

Chemistry, pharmacology, and behavioral studies identify chiral cyclopropanes as selective α4β2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile. Part II.

Zhang HK, Yu LF, Eaton JB, Whiteaker P, Onajole OK, Hanania T, Brunner D, Lukas RJ, Kozikowski AP. Zhang HK, et al. J Med Chem. 2013 Jul 11;56(13):5495-504. doi: 10.1021/jm400510u. Epub 2013 Jun 26. J Med Chem. 2013. PMID: 23734673 Free PMC article.

From α4β2 Nicotinic Ligands to the Discovery of σ1 Receptor Ligands: Pharmacophore Analysis and Rational Design.

Yu LF, Zhang HK, Gunosewoyo H, Kozikowski AP. Yu LF, et al. ACS Med Chem Lett. 2012 Dec 13;3(12):1054-1058. doi: 10.1021/ml3002715. ACS Med Chem Lett. 2012. PMID: 23641311 Free PMC article.

A novel nicotinic mechanism underlies β-amyloid-induced neuronal hyperexcitation.

Liu Q, Xie X, Lukas RJ, St John PA, Wu J. Liu Q, et al. J Neurosci. 2013 Apr 24;33(17):7253-63. doi: 10.1523/JNEUROSCI.3235-12.2013. J Neurosci. 2013. PMID: 23616534 Free PMC article.

Pharmacokinetics and brain penetration of LF-3-88, (2-[5-[5-(2(S)-azetidinylmethoxyl)-3-pyridyl]-3-isoxazolyl]ethanol), a selective α4β2-nAChR partial agonist and promising antidepressant.

Yuan Y, Yu LF, Qiu X, Kozikowski AP, van Breemen RB. Yuan Y, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jan 1;912:38-42. doi: 10.1016/j.jchromb.2012.11.011. Epub 2012 Nov 23. J Chromatogr B Analyt Technol Biomed Life Sci. 2013. PMID: 23246847 Free PMC article.

Discovery of highly potent and selective α4β2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II.

Yu LF, Eaton JB, Fedolak A, Zhang HK, Hanania T, Brunner D, Lukas RJ, Kozikowski AP. Yu LF, et al. J Med Chem. 2012 Nov 26;55(22):9998-10009. doi: 10.1021/jm301177j. Epub 2012 Nov 2. J Med Chem. 2012. PMID: 23092294 Free PMC article.

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