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Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells.
Cell Stem Cell. 2022 Jan 6;29(1):36-51.e6. doi: 10.1016/j.stem.2021.10.010. Epub 2021 Dec 1.
Cell Stem Cell. 2022.
PMID: 34856121
Free PMC article.
Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system.
Workman MJ, Mahe MM, Trisno S, Poling HM, Watson CL, Sundaram N, Chang CF, Schiesser J, Aubert P, Stanley EG, Elefanty AG, Miyaoka Y, Mandegar MA, Conklin BR, Neunlist M, Brugmann SA, Helmrath MA, Wells JM.
Workman MJ, et al.
Nat Med. 2017 Jan;23(1):49-59. doi: 10.1038/nm.4233. Epub 2016 Nov 21.
Nat Med. 2017.
PMID: 27869805
Free PMC article.
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Generating human intestinal tissues from pluripotent stem cells to study development and disease.
Sinagoga KL, Wells JM.
Sinagoga KL, et al.
EMBO J. 2015 May 5;34(9):1149-63. doi: 10.15252/embj.201490686. Epub 2015 Mar 19.
EMBO J. 2015.
PMID: 25792515
Free PMC article.
Review.
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Developmental biology. Regional identity of gut stem cells--one gene to rule them all.
Wells JM.
Wells JM.
Nat Rev Gastroenterol Hepatol. 2015 Mar;12(3):125-6. doi: 10.1038/nrgastro.2015.22. Epub 2015 Feb 3.
Nat Rev Gastroenterol Hepatol. 2015.
PMID: 25645971
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Building additional complexity to in vitro-derived intestinal tissues.
Brugmann SA, Wells JM.
Brugmann SA, et al.
Stem Cell Res Ther. 2013;4 Suppl 1(Suppl 1):S1. doi: 10.1186/scrt362. Epub 2013 Dec 20.
Stem Cell Res Ther. 2013.
PMID: 24565179
Free PMC article.
Review.
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