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In vitro-in vivo correlations for nicotine transdermal delivery systems evaluated by both in vitro skin permeation (IVPT) and in vivo serum pharmacokinetics under the influence of transient heat application.
Shin SH, Thomas S, Raney SG, Ghosh P, Hammell DC, El-Kamary SS, Chen WH, Billington MM, Hassan HE, Stinchcomb AL. Shin SH, et al. J Control Release. 2018 Jan 28;270:76-88. doi: 10.1016/j.jconrel.2017.11.034. Epub 2017 Nov 22. J Control Release. 2018. PMID: 29175139
A fully validated LC-MS/MS method for simultaneous determination of nicotine and its metabolite cotinine in human serum and its application to a pharmacokinetic study after using nicotine transdermal delivery systems with standard heat application in adult smokers.
Abdallah IA, Hammell DC, Stinchcomb AL, Hassan HE. Abdallah IA, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 May 1;1020:67-77. doi: 10.1016/j.jchromb.2016.03.020. Epub 2016 Mar 19. J Chromatogr B Analyt Technol Biomed Life Sci. 2016. PMID: 27023159