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Interleukin 6 Blockade With Tocilizumab Diminishes Indices of Inflammation That Are Linked to Mortality in Treated Human Immunodeficiency Virus Infection.
Funderburg NT, Shive CL, Chen Z, Tatsuoka C, Bowman ER, Longenecker CT, McComsey GA, Clagett BM, Dorazio D, Freeman ML, Sieg SF, Moisi D, Anthony DD, Jacobson JM, Stein SL, Calabrese LH, Landay A, Flexner C, Crawford KW, Capparelli EV, Rodriguez B, Lederman MM. Funderburg NT, et al. Clin Infect Dis. 2023 Jul 26;77(2):272-279. doi: 10.1093/cid/ciad199. Clin Infect Dis. 2023. PMID: 37011013 Free PMC article. Clinical Trial.
Cycling CD4+ T cells in HIV-infected immune nonresponders have mitochondrial dysfunction.
Younes SA, Talla A, Pereira Ribeiro S, Saidakova EV, Korolevskaya LB, Shmagel KV, Shive CL, Freeman ML, Panigrahi S, Zweig S, Balderas R, Margolis L, Douek DC, Anthony DD, Pandiyan P, Cameron M, Sieg SF, Calabrese LH, Rodriguez B, Lederman MM. Younes SA, et al. J Clin Invest. 2018 Nov 1;128(11):5083-5094. doi: 10.1172/JCI120245. Epub 2018 Oct 15. J Clin Invest. 2018. PMID: 30320604 Free PMC article. Clinical Trial.
The mycobiome in HIV.
Hager CL, Ghannoum MA. Hager CL, et al. Curr Opin HIV AIDS. 2018 Jan;13(1):69-72. doi: 10.1097/COH.0000000000000432. Curr Opin HIV AIDS. 2018. PMID: 29028668 Free PMC article. Review.
IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection.
Younes SA, Freeman ML, Mudd JC, Shive CL, Reynaldi A, Panigrahi S, Estes JD, Deleage C, Lucero C, Anderson J, Schacker TW, Davenport MP, McCune JM, Hunt PW, Lee SA, Serrano-Villar S, Debernardo RL, Jacobson JM, Canaday DH, Sekaly RP, Rodriguez B, Sieg SF, Lederman MM. Younes SA, et al. J Clin Invest. 2016 Jul 1;126(7):2745-56. doi: 10.1172/JCI85996. Epub 2016 Jun 20. J Clin Invest. 2016. PMID: 27322062 Free PMC article.
Inflammation Perturbs the IL-7 Axis, Promoting Senescence and Exhaustion that Broadly Characterize Immune Failure in Treated HIV Infection.
Shive CL, Clagett B, McCausland MR, Mudd JC, Funderburg NT, Freeman ML, Younes SA, Ferrari BM, Rodriguez B, McComsey GA, Calabrese LH, Sieg SF, Lederman MM. Shive CL, et al. J Acquir Immune Defic Syndr. 2016 Apr 15;71(5):483-92. doi: 10.1097/QAI.0000000000000913. J Acquir Immune Defic Syndr. 2016. PMID: 26627102 Free PMC article.