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Nature of epigenetic aging from a single-cell perspective.
Tarkhov AE, Lindstrom-Vautrin T, Zhang S, Ying K, Moqri M, Zhang B, Tyshkovskiy A, Levy O, Gladyshev VN. Tarkhov AE, et al. Among authors: tyshkovskiy a. Nat Aging. 2024 May 9. doi: 10.1038/s43587-024-00616-0. Online ahead of print. Nat Aging. 2024. PMID: 38724733
A disease similarity approach identifies short-lived Niemann-Pick type C disease mice with accelerated brain aging as a novel mouse model for Alzheimer's disease and aging research.
Gujjala VA, Klimek I, Abyadeh M, Tyshkovskiy A, Oz N, Castro JP, Gladyshev VN, Newton J, Kaya A. Gujjala VA, et al. Among authors: tyshkovskiy a. bioRxiv [Preprint]. 2024 Apr 23:2024.04.19.590328. doi: 10.1101/2024.04.19.590328. bioRxiv. 2024. PMID: 38712089 Free PMC article. Preprint.
AgeMeta: Quantitative Gene Expression Database of Mammalian Aging.
Tikhonov S, Batin M, Gladyshev VN, Dmitriev SE, Tyshkovskiy A. Tikhonov S, et al. Among authors: tyshkovskiy a. Biochemistry (Mosc). 2024 Feb;89(2):313-321. doi: 10.1134/S000629792402010X. Biochemistry (Mosc). 2024. PMID: 38622098 Free article.
A torpor-like state (TLS) in mice slows blood epigenetic aging and prolongs healthspan.
Jayne L, Lavin-Peter A, Roessler J, Tyshkovskiy A, Antoszewski M, Ren E, Markovski A, Sun S, Yao H, Sankaran VG, Gladyshev VN, Brooke RT, Horvath S, Griffith EC, Hrvatin S. Jayne L, et al. Among authors: tyshkovskiy a. bioRxiv [Preprint]. 2024 Mar 25:2024.03.20.585828. doi: 10.1101/2024.03.20.585828. bioRxiv. 2024. PMID: 38585858 Free PMC article. Preprint.
Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology.
Aguado J, Amarilla AA, Taherian Fard A, Albornoz EA, Tyshkovskiy A, Schwabenland M, Chaggar HK, Modhiran N, Gómez-Inclán C, Javed I, Baradar AA, Liang B, Peng L, Dharmaratne M, Pietrogrande G, Padmanabhan P, Freney ME, Parry R, Sng JDJ, Isaacs A, Khromykh AA, Valenzuela Nieto G, Rojas-Fernandez A, Davis TP, Prinz M, Bengsch B, Gladyshev VN, Woodruff TM, Mar JC, Watterson D, Wolvetang EJ. Aguado J, et al. Among authors: tyshkovskiy a. Nat Aging. 2023 Dec;3(12):1561-1575. doi: 10.1038/s43587-023-00519-6. Epub 2023 Nov 13. Nat Aging. 2023. PMID: 37957361 Free PMC article.
Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice.
Zhang Z, Tian X, Lu JY, Boit K, Ablaeva J, Zakusilo FT, Emmrich S, Firsanov D, Rydkina E, Biashad SA, Lu Q, Tyshkovskiy A, Gladyshev VN, Horvath S, Seluanov A, Gorbunova V. Zhang Z, et al. Among authors: tyshkovskiy a. Nature. 2023 Sep;621(7977):196-205. doi: 10.1038/s41586-023-06463-0. Epub 2023 Aug 23. Nature. 2023. PMID: 37612507 Free PMC article.
Multi-omic rejuvenation and life span extension on exposure to youthful circulation.
Zhang B, Lee DE, Trapp A, Tyshkovskiy A, Lu AT, Bareja A, Kerepesi C, McKay LK, Shindyapina AV, Dmitriev SE, Baht GS, Horvath S, Gladyshev VN, White JP. Zhang B, et al. Among authors: tyshkovskiy a. Nat Aging. 2023 Aug;3(8):948-964. doi: 10.1038/s43587-023-00451-9. Epub 2023 Jul 27. Nat Aging. 2023. PMID: 37500973 Free PMC article.
Chemically induced reprogramming to reverse cellular aging.
Yang JH, Petty CA, Dixon-McDougall T, Lopez MV, Tyshkovskiy A, Maybury-Lewis S, Tian X, Ibrahim N, Chen Z, Griffin PT, Arnold M, Li J, Martinez OA, Behn A, Rogers-Hammond R, Angeli S, Gladyshev VN, Sinclair DA. Yang JH, et al. Among authors: tyshkovskiy a. Aging (Albany NY). 2023 Jul 12;15(13):5966-5989. doi: 10.18632/aging.204896. Epub 2023 Jul 12. Aging (Albany NY). 2023. PMID: 37437248 Free PMC article.
32 results