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Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation.
Misheva M, Kotzamanis K, Davies LC, Tyrrell VJ, Rodrigues PRS, Benavides GA, Hinz C, Murphy RC, Kennedy P, Taylor PR, Rosas M, Jones SA, McLaren JE, Deshpande S, Andrews R, Schebb NH, Czubala MA, Gurney M, Aldrovandi M, Meckelmann SW, Ghazal P, Darley-Usmar V, White DA, O'Donnell VB. Misheva M, et al. Among authors: tyrrell vj. Nat Commun. 2022 Jan 10;13(1):139. doi: 10.1038/s41467-021-27766-8. Nat Commun. 2022. PMID: 35013270 Free PMC article.
Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis.
Lauder SN, Allen-Redpath K, Slatter DA, Aldrovandi M, O'Connor A, Farewell D, Percy CL, Molhoek JE, Rannikko S, Tyrrell VJ, Ferla S, Milne GL, Poole AW, Thomas CP, Obaji S, Taylor PR, Jones SA, de Groot PG, Urbanus RT, Hörkkö S, Uderhardt S, Ackermann J, Vince Jenkins P, Brancale A, Krönke G, Collins PW, O'Donnell VB. Lauder SN, et al. Among authors: tyrrell vj. Sci Signal. 2017 Nov 28;10(507):eaan2787. doi: 10.1126/scisignal.aan2787. Sci Signal. 2017. PMID: 29184033 Free PMC article.
Enzymatically oxidized phospholipids restore thrombin generation in coagulation factor deficiencies.
Slatter DA, Percy CL, Allen-Redpath K, Gajsiewicz JM, Brooks NJ, Clayton A, Tyrrell VJ, Rosas M, Lauder SN, Watson A, Dul M, Garcia-Diaz Y, Aldrovandi M, Heurich M, Hall J, Morrissey JH, Lacroix-Desmazes S, Delignat S, Jenkins PV, Collins PW, O'Donnell VB. Slatter DA, et al. Among authors: tyrrell vj. JCI Insight. 2018 Mar 22;3(6):e98459. doi: 10.1172/jci.insight.98459. JCI Insight. 2018. PMID: 29563336 Free PMC article.
Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity.
Allen-Redpath K, Aldrovandi M, Lauder SN, Gketsopoulou A, Tyrrell VJ, Slatter DA, Andrews R, Watkins WJ, Atkinson G, McNeill E, Gilfedder A, Protty M, Burston J, Johnson SRC, Rodrigues PRS, Jones DO, Lee R, Handa A, Channon K, Obaji S, Alvarez-Jarreta J, Krönke G, Ackermann J, Jenkins PV, Collins PW, O'Donnell VB. Allen-Redpath K, et al. Among authors: tyrrell vj. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):8038-8047. doi: 10.1073/pnas.1814409116. Epub 2019 Apr 3. Proc Natl Acad Sci U S A. 2019. PMID: 30944221 Free PMC article.
Revising the structure of a new eicosanoid from human platelets to 8,9-11,12-diepoxy-13-hydroxyeicosadienoic acid.
Kornilov A, Kennedy PD, Aldrovandi M, Watson AJA, Hinz C, Harless B, Colombo J, Maxey KM, Tyrrell VJ, Simon M, Aggarwal VK, Boeglin WE, Brash AR, Murphy RC, O'Donnell VB. Kornilov A, et al. Among authors: tyrrell vj. J Biol Chem. 2019 Jun 7;294(23):9225-9238. doi: 10.1074/jbc.RA119.008915. Epub 2019 May 6. J Biol Chem. 2019. PMID: 31061099 Free PMC article.
32 results