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Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase from Mycobacterium tuberculosis.
Ribeiro JA, Hammer A, Libreros-Zúñiga GA, Chavez-Pacheco SM, Tyrakis P, de Oliveira GS, Kirkman T, El Bakali J, Rocco SA, Sforça ML, Parise-Filho R, Coyne AG, Blundell TL, Abell C, Dias MVB. Ribeiro JA, et al. Among authors: tyrakis p. ACS Infect Dis. 2020 Aug 14;6(8):2192-2201. doi: 10.1021/acsinfecdis.0c00263. Epub 2020 Jul 10. ACS Infect Dis. 2020. PMID: 32603583
Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects.
Tyrakis PA, Yurkovich ME, Sciacovelli M, Papachristou EK, Bridges HR, Gaude E, Schreiner A, D'Santos C, Hirst J, Hernandez-Fernaud J, Springett R, Griffiths JR, Frezza C. Tyrakis PA, et al. Cell Rep. 2017 Oct 24;21(4):1036-1047. doi: 10.1016/j.celrep.2017.09.092. Cell Rep. 2017. PMID: 29069586 Free PMC article.
S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate.
Tyrakis PA, Palazon A, Macias D, Lee KL, Phan AT, Veliça P, You J, Chia GS, Sim J, Doedens A, Abelanet A, Evans CE, Griffiths JR, Poellinger L, Goldrath AW, Johnson RS. Tyrakis PA, et al. Nature. 2016 Dec 8;540(7632):236-241. doi: 10.1038/nature20165. Epub 2016 Oct 26. Nature. 2016. PMID: 27798602 Free PMC article.
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression.
Palazon A, Tyrakis PA, Macias D, Veliça P, Rundqvist H, Fitzpatrick S, Vojnovic N, Phan AT, Loman N, Hedenfalk I, Hatschek T, Lövrot J, Foukakis T, Goldrath AW, Bergh J, Johnson RS. Palazon A, et al. Among authors: tyrakis pa. Cancer Cell. 2017 Nov 13;32(5):669-683.e5. doi: 10.1016/j.ccell.2017.10.003. Cancer Cell. 2017. PMID: 29136509 Free PMC article.
The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia.
Sim J, Cowburn AS, Palazon A, Madhu B, Tyrakis PA, Macías D, Bargiela DM, Pietsch S, Gralla M, Evans CE, Kittipassorn T, Chey YCJ, Branco CM, Rundqvist H, Peet DJ, Johnson RS. Sim J, et al. Among authors: tyrakis pa. Cell Metab. 2018 Apr 3;27(4):898-913.e7. doi: 10.1016/j.cmet.2018.02.020. Cell Metab. 2018. PMID: 29617647 Free PMC article.
The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function.
Foskolou IP, Cunha PP, Sánchez-López E, Minogue EA, Nicolet BP, Guislain A, Jorgensen C, Kostidis S, Zandhuis ND, Barbieri L, Bargiela D, Nathanael D, Tyrakis PA, Palazon A, Giera M, Wolkers MC, Johnson RS. Foskolou IP, et al. Among authors: tyrakis pa. Cell Rep. 2023 Sep 26;42(9):113013. doi: 10.1016/j.celrep.2023.113013. Epub 2023 Aug 24. Cell Rep. 2023. PMID: 37632752 Free article.