Tyndall JD - Search Results

1

CtHtrA: the lynchpin of the chlamydial surface and a promising therapeutic target.

Marsh JW, Ong VA, Lott WB, Timms P, Tyndall JD, Huston WM. Marsh JW, et al. Among authors: tyndall jd. Future Microbiol. 2017 Jul;12:817-829. doi: 10.2217/fmb-2017-0017. Epub 2017 Jun 8. Future Microbiol. 2017. PMID: 28593794 Review.

2

Unique residues involved in activation of the multitasking protease/chaperone HtrA from Chlamydia trachomatis.

Huston WM, Tyndall JD, Lott WB, Stansfield SH, Timms P. Huston WM, et al. Among authors: tyndall jd. PLoS One. 2011;6(9):e24547. doi: 10.1371/journal.pone.0024547. Epub 2011 Sep 8. PLoS One. 2011. PMID: 21931748 Free PMC article.

3

the active site residue V266 of Chlamydial HtrA is critical for substrate binding during both in vitro and in vivo conditions.

Gloeckl S, Tyndall JD, Stansfield SH, Timms P, Huston WM. Gloeckl S, et al. Among authors: tyndall jd. J Mol Microbiol Biotechnol. 2012;22(1):10-6. doi: 10.1159/000336312. Epub 2012 Feb 21. J Mol Microbiol Biotechnol. 2012. PMID: 22353774 Free article.

4

Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis.

Gloeckl S, Ong VA, Patel P, Tyndall JD, Timms P, Beagley KW, Allan JA, Armitage CW, Turnbull L, Whitchurch CB, Merdanovic M, Ehrmann M, Powers JC, Oleksyszyn J, Verdoes M, Bogyo M, Huston WM. Gloeckl S, et al. Among authors: tyndall jd. Mol Microbiol. 2013 Aug;89(4):676-89. doi: 10.1111/mmi.12306. Epub 2013 Jul 12. Mol Microbiol. 2013. PMID: 23796320 Free article.

5

Proteolytic activation of Chlamydia trachomatis HTRA is mediated by PDZ1 domain interactions with protease domain loops L3 and LC and beta strand β5.

Marsh JW, Lott WB, Tyndall JD, Huston WW. Marsh JW, et al. Among authors: tyndall jd. Cell Mol Biol Lett. 2013 Dec;18(4):522-37. doi: 10.2478/s11658-013-0103-2. Epub 2013 Sep 13. Cell Mol Biol Lett. 2013. PMID: 24036669 Free PMC article.

6

A Chlamydia trachomatis strain with a chemically generated amino acid substitution (P370L) in the cthtrA gene shows reduced elementary body production.

Marsh JW, Wee BA, Tyndall JD, Lott WB, Bastidas RJ, Caldwell HD, Valdivia RH, Kari L, Huston WM. Marsh JW, et al. Among authors: tyndall jd. BMC Microbiol. 2015 Sep 30;15:194. doi: 10.1186/s12866-015-0533-2. BMC Microbiol. 2015. PMID: 26424482 Free PMC article.

7

Chlamydia Serine Protease Inhibitor, targeting HtrA, as a New Treatment for Koala Chlamydia infection.

Lawrence A, Fraser T, Gillett A, Tyndall JD, Timms P, Polkinghorne A, Huston WM. Lawrence A, et al. Among authors: tyndall jd. Sci Rep. 2016 Aug 17;6:31466. doi: 10.1038/srep31466. Sci Rep. 2016. PMID: 27530689 Free PMC article.

8

Proteases and protease inhibitors in infectious diseases.

Agbowuro AA, Huston WM, Gamble AB, Tyndall JDA. Agbowuro AA, et al. Med Res Rev. 2018 Jul;38(4):1295-1331. doi: 10.1002/med.21475. Epub 2017 Nov 17. Med Res Rev. 2018. PMID: 29149530 Review.

9

Structure-activity analysis of peptidic Chlamydia HtrA inhibitors.

Agbowuro AA, Hwang J, Peel E, Mazraani R, Springwald A, Marsh JW, McCaughey L, Gamble AB, Huston WM, Tyndall JDA. Agbowuro AA, et al. Bioorg Med Chem. 2019 Sep 15;27(18):4185-4199. doi: 10.1016/j.bmc.2019.07.049. Epub 2019 Jul 30. Bioorg Med Chem. 2019. PMID: 31395511

10

Optimization of peptide-based inhibitors targeting the HtrA serine protease in Chlamydia: Design, synthesis and biological evaluation of pyridone-based and N-Capping group-modified analogues.

Hwang J, Strange N, Phillips MJA, Krause AL, Heywood A, Gamble AB, Huston WM, Tyndall JDA. Hwang J, et al. Eur J Med Chem. 2021 Nov 15;224:113692. doi: 10.1016/j.ejmech.2021.113692. Epub 2021 Jul 7. Eur J Med Chem. 2021. PMID: 34265463

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