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Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.
J Biol Chem. 2015 Aug 28;290(35):21376-92. doi: 10.1074/jbc.M115.671248. Epub 2015 Jul 7.
J Biol Chem. 2015.
PMID: 26152717
Free PMC article.
TPC1 has two variant isoforms, and their removal has different effects on endo-lysosomal functions compared to loss of TPC2.
Ruas M, Chuang KT, Davis LC, Al-Douri A, Tynan PW, Tunn R, Teboul L, Galione A, Parrington J.
Ruas M, et al. Among authors: tynan pw.
Mol Cell Biol. 2014 Nov;34(21):3981-92. doi: 10.1128/MCB.00113-14. Epub 2014 Aug 18.
Mol Cell Biol. 2014.
PMID: 25135478
Free PMC article.
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Absence of intracellular ion channels TPC1 and TPC2 leads to mature-onset obesity in male mice, due to impaired lipid availability for thermogenesis in brown adipose tissue.
Lear PV, González-Touceda D, Porteiro Couto B, Viaño P, Guymer V, Remzova E, Tunn R, Chalasani A, García-Caballero T, Hargreaves IP, Tynan PW, Christian HC, Nogueiras R, Parrington J, Diéguez C.
Lear PV, et al. Among authors: tynan pw.
Endocrinology. 2015 Mar;156(3):975-86. doi: 10.1210/en.2014-1766. Epub 2014 Dec 29.
Endocrinology. 2015.
PMID: 25545384
Free PMC article.
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Defective platelet function in Niemann-Pick disease type C1.
Chen OCW, Colaco A, Davis LC, Kiskin FN, Farhat NY, Speak AO, Smith DA, Morris L, Eden E, Tynan P, Churchill GC, Galione A, Porter FD, Platt FM.
Chen OCW, et al.
JIMD Rep. 2020 Sep 12;56(1):46-57. doi: 10.1002/jmd2.12148. eCollection 2020 Nov.
JIMD Rep. 2020.
PMID: 33204596
Free PMC article.
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Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway.
Fineran P, Lloyd-Evans E, Lack NA, Platt N, Davis LC, Morgan AJ, Höglinger D, Tatituri RVV, Clark S, Williams IM, Tynan P, Al Eisa N, Nazarova E, Williams A, Galione A, Ory DS, Besra GS, Russell DG, Brenner MB, Sim E, Platt FM.
Fineran P, et al.
Wellcome Open Res. 2016 Nov 18;1:18. doi: 10.12688/wellcomeopenres.10036.2.
Wellcome Open Res. 2016.
PMID: 28008422
Free PMC article.
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Presynaptic NMDARs in the hippocampus facilitate transmitter release at theta frequency.
McGuinness L, Taylor C, Taylor RD, Yau C, Langenhan T, Hart ML, Christian H, Tynan PW, Donnelly P, Emptage NJ.
McGuinness L, et al. Among authors: tynan pw.
Neuron. 2010 Dec 22;68(6):1109-27. doi: 10.1016/j.neuron.2010.11.023.
Neuron. 2010.
PMID: 21172613
Free article.
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Uptake and destruction of 125I-CSF-1 by peritoneal exudate macrophages.
Guilbert LJ, Tynan PW, Stanley ER.
Guilbert LJ, et al. Among authors: tynan pw.
J Cell Biochem. 1986;31(3):203-16. doi: 10.1002/jcb.240310303.
J Cell Biochem. 1986.
PMID: 2978971
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Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy.
Tushinski RJ, Oliver IT, Guilbert LJ, Tynan PW, Warner JR, Stanley ER.
Tushinski RJ, et al. Among authors: tynan pw.
Cell. 1982 Jan;28(1):71-81. doi: 10.1016/0092-8674(82)90376-2.
Cell. 1982.
PMID: 6978185
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