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A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells.
Sohail M, Shkreta L, Toutant J, Rabea S, Babeu JP, Huard C, Coulombe-Huntington J, Delannoy A, Placet M, Geha S, Gendron FP, Boudreau F, Tyers M, Grierson DS, Chabot B. Sohail M, et al. Among authors: tyers m. NAR Cancer. 2021 May 25;3(2):zcab019. doi: 10.1093/narcan/zcab019. eCollection 2021 Jun. NAR Cancer. 2021. PMID: 34316707 Free PMC article.
The BioGRID interaction database: 2019 update.
Oughtred R, Stark C, Breitkreutz BJ, Rust J, Boucher L, Chang C, Kolas N, O'Donnell L, Leung G, McAdam R, Zhang F, Dolma S, Willems A, Coulombe-Huntington J, Chatr-Aryamontri A, Dolinski K, Tyers M. Oughtred R, et al. Among authors: tyers m. Nucleic Acids Res. 2019 Jan 8;47(D1):D529-D541. doi: 10.1093/nar/gky1079. Nucleic Acids Res. 2019. PMID: 30476227 Free PMC article.
Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development.
Jacques S, van der Sloot AM, C Huard C, Coulombe-Huntington J, Tsao S, Tollis S, Bertomeu T, Culp EJ, Pallant D, Cook MA, Bonneil E, Thibault P, Wright GD, Tyers M. Jacques S, et al. Among authors: tyers m. Genetics. 2020 Apr;214(4):1103-1120. doi: 10.1534/genetics.119.302851. Epub 2020 Feb 24. Genetics. 2020. PMID: 32094149 Free PMC article.
Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells.
Benslimane Y, Bertomeu T, Coulombe-Huntington J, McQuaid M, Sánchez-Osuna M, Papadopoli D, Avizonis D, Russo MST, Huard C, Topisirovic I, Wurtele H, Tyers M, Harrington L. Benslimane Y, et al. Among authors: tyers m. Mol Cell. 2020 Sep 3;79(5):846-856.e8. doi: 10.1016/j.molcel.2020.07.010. Epub 2020 Aug 4. Mol Cell. 2020. PMID: 32755594 Free article.
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality.
Mast FD, Navare AT, van der Sloot AM, Coulombe-Huntington J, Rout MP, Baliga NS, Kaushansky A, Chait BT, Aderem A, Rice CM, Sali A, Tyers M, Aitchison JD. Mast FD, et al. Among authors: tyers m. J Cell Biol. 2020 Oct 5;219(10):e202006159. doi: 10.1083/jcb.202006159. J Cell Biol. 2020. PMID: 32785687 Free PMC article.
The BioGRID database: A comprehensive biomedical resource of curated protein, genetic, and chemical interactions.
Oughtred R, Rust J, Chang C, Breitkreutz BJ, Stark C, Willems A, Boucher L, Leung G, Kolas N, Zhang F, Dolma S, Coulombe-Huntington J, Chatr-Aryamontri A, Dolinski K, Tyers M. Oughtred R, et al. Among authors: tyers m. Protein Sci. 2021 Jan;30(1):187-200. doi: 10.1002/pro.3978. Epub 2020 Nov 23. Protein Sci. 2021. PMID: 33070389 Free PMC article.
UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.
Chagraoui J, Girard S, Spinella JF, Simon L, Bonneil E, Mayotte N, MacRae T, Coulombe-Huntington J, Bertomeu T, Moison C, Tomellini E, Thibault P, Tyers M, Marinier A, Sauvageau G. Chagraoui J, et al. Among authors: tyers m. Cell Stem Cell. 2021 Jan 7;28(1):48-62.e6. doi: 10.1016/j.stem.2020.12.002. Cell Stem Cell. 2021. PMID: 33417871 Free article.
A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition.
Benslimane Y, Sánchez-Osuna M, Coulombe-Huntington J, Bertomeu T, Henry D, Huard C, Bonneil É, Thibault P, Tyers M, Harrington L. Benslimane Y, et al. Among authors: tyers m. Aging Cell. 2021 Apr;20(4):e13331. doi: 10.1111/acel.13331. Epub 2021 Mar 4. Aging Cell. 2021. PMID: 33660365 Free PMC article.
339 results