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Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models.
Mol Neurodegener. 2024 Jan 25;19(1):12. doi: 10.1186/s13024-024-00701-3.
Mol Neurodegener. 2024.
PMID: 38273330
Free PMC article.
Partial loss of MCU mitigates pathology in vivo across a diverse range of neurodegenerative disease models.
Twyning MJ, Tufi R, Gleeson TP, Kolodziej KM, Campesan S, Terriente-Felix A, Collins L, De Lazzari F, Giorgini F, Whitworth AJ.
Twyning MJ, et al.
Cell Rep. 2024 Feb 27;43(2):113681. doi: 10.1016/j.celrep.2024.113681. Epub 2024 Jan 18.
Cell Rep. 2024.
PMID: 38236772
Free article.
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Decreasing pdzd8-mediated mito-ER contacts improves organismal fitness and mitigates Aβ42 toxicity.
Hewitt VL, Miller-Fleming L, Twyning MJ, Andreazza S, Mattedi F, Prudent J, Polleux F, Vagnoni A, Whitworth AJ.
Hewitt VL, et al. Among authors: twyning mj.
Life Sci Alliance. 2022 Jul 13;5(11):e202201531. doi: 10.26508/lsa.202201531. Print 2022 Nov.
Life Sci Alliance. 2022.
PMID: 35831024
Free PMC article.
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