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Nonhuman primates are protected from smallpox virus or monkeypox virus challenges by the antiviral drug ST-246.
Huggins J, Goff A, Hensley L, Mucker E, Shamblin J, Wlazlowski C, Johnson W, Chapman J, Larsen T, Twenhafel N, Karem K, Damon IK, Byrd CM, Bolken TC, Jordan R, Hruby D. Huggins J, et al. Antimicrob Agents Chemother. 2009 Jun;53(6):2620-5. doi: 10.1128/AAC.00021-09. Epub 2009 Apr 6. Antimicrob Agents Chemother. 2009. PMID: 19349521 Free PMC article.
ST-246 antiviral efficacy in a nonhuman primate monkeypox model: determination of the minimal effective dose and human dose justification.
Jordan R, Goff A, Frimm A, Corrado ML, Hensley LE, Byrd CM, Mucker E, Shamblin J, Bolken TC, Wlazlowski C, Johnson W, Chapman J, Twenhafel N, Tyavanagimatt S, Amantana A, Chinsangaram J, Hruby DE, Huggins J. Jordan R, et al. Antimicrob Agents Chemother. 2009 May;53(5):1817-22. doi: 10.1128/AAC.01596-08. Epub 2009 Feb 17. Antimicrob Agents Chemother. 2009. PMID: 19223621 Free PMC article. Clinical Trial.
Natural History of Aerosol Exposure with Marburg Virus in Rhesus Macaques.
Ewers EC, Pratt WD, Twenhafel NA, Shamblin J, Donnelly G, Esham H, Wlazlowski C, Johnson JC, Botto M, Hensley LE, Goff AJ. Ewers EC, et al. Among authors: twenhafel na. Viruses. 2016 Mar 30;8(4):87. doi: 10.3390/v8040087. Viruses. 2016. PMID: 27043611 Free PMC article.
Evaluation of Lassa antiviral compound ST-193 in a guinea pig model.
Cashman KA, Smith MA, Twenhafel NA, Larson RA, Jones KF, Allen RD 3rd, Dai D, Chinsangaram J, Bolken TC, Hruby DE, Amberg SM, Hensley LE, Guttieri MC. Cashman KA, et al. Among authors: twenhafel na. Antiviral Res. 2011 Apr;90(1):70-9. doi: 10.1016/j.antiviral.2011.02.012. Epub 2011 Mar 1. Antiviral Res. 2011. PMID: 21371508 Free PMC article.
Hamsters Expressing Human Angiotensin-Converting Enzyme 2 Develop Severe Disease following Exposure to SARS-CoV-2.
Golden JW, Li R, Cline CR, Zeng X, Mucker EM, Fuentes-Lao AJ, Spik KW, Williams JA, Twenhafel N, Davis N, Moore JL, Stevens S, Blue E, Garrison AR, Larson DD, Stewart R, Kunzler M, Liu Y, Wang Z, Hooper JW. Golden JW, et al. mBio. 2022 Feb 22;13(1):e0290621. doi: 10.1128/mbio.02906-21. Epub 2022 Jan 25. mBio. 2022. PMID: 35073750 Free PMC article.
37 results