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Synthesis by diastereomeric resolution, biochemical evaluation and molecular modelling of chiral 3-hydroxyl b-lactam microtubule-targeting agents for the treatment of triple negative breast and chemoresistant colorectal cancers.
McLoughlin EC, Twamley B, O'Brien JE, Hannon Barroeta P, Zisterer DM, Meegan MJ, O'Boyle NM. McLoughlin EC, et al. Among authors: twamley b. Bioorg Chem. 2023 Dec;141:106877. doi: 10.1016/j.bioorg.2023.106877. Epub 2023 Sep 30. Bioorg Chem. 2023. PMID: 37804699 Free article.
Structure of (R,R)-4-bromo-2-{4-[4-bromo-1-(4-toluene-sulfon-yl)-1H-pyrrol-2-yl]-1,3-di-nitro-butan-2-yl}-1-(4-toluene-sulfon-yl)-1H-pyrrole, another ostensible by-product in the synthesis of geminal-dimethyl hydro-dipyrrins.
Sample HC, Twamley B, Senge MO. Sample HC, et al. Among authors: twamley b. Acta Crystallogr E Crystallogr Commun. 2023 Jun 2;79(Pt 7):592-595. doi: 10.1107/S2056989023004644. eCollection 2023 Jun 1. Acta Crystallogr E Crystallogr Commun. 2023. PMID: 37601579 Free PMC article.
Structures of S-(pyridin-2-yl) 4-nitro-benzo-thio-ate, S-(pyridin-2-yl) 4-methyl-benzo-thio-ate and S-(pyridin-2-yl) 4-meth-oxy-benzo-thio-ate: building blocks for low-symmetry multifunctional tetra-pyrroles.
Sample HC, Twamley B, Senge MO. Sample HC, et al. Among authors: twamley b. Acta Crystallogr E Crystallogr Commun. 2023 Feb 9;79(Pt 3):157-162. doi: 10.1107/S2056989023001056. eCollection 2023 Feb 1. Acta Crystallogr E Crystallogr Commun. 2023. PMID: 36909990 Free PMC article.
210 results