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CD8+ T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy.
Huseni MA, Wang L, Klementowicz JE, Yuen K, Breart B, Orr C, Liu LF, Li Y, Gupta V, Li C, Rishipathak D, Peng J, Şenbabaoǧlu Y, Modrusan Z, Keerthivasan S, Madireddi S, Chen YJ, Fraser EJ, Leng N, Hamidi H, Koeppen H, Ziai J, Hashimoto K, Fassò M, Williams P, McDermott DF, Rosenberg JE, Powles T, Emens LA, Hegde PS, Mellman I, Turley SJ, Wilson MS, Mariathasan S, Molinero L, Merchant M, West NR. Huseni MA, et al. Among authors: turley sj. Cell Rep Med. 2023 Jan 17;4(1):100878. doi: 10.1016/j.xcrm.2022.100878. Epub 2023 Jan 3. Cell Rep Med. 2023. PMID: 36599350 Free PMC article.
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.
Mariathasan S, Turley SJ, Nickles D, Castiglioni A, Yuen K, Wang Y, Kadel EE III, Koeppen H, Astarita JL, Cubas R, Jhunjhunwala S, Banchereau R, Yang Y, Guan Y, Chalouni C, Ziai J, Şenbabaoğlu Y, Santoro S, Sheinson D, Hung J, Giltnane JM, Pierce AA, Mesh K, Lianoglou S, Riegler J, Carano RAD, Eriksson P, Höglund M, Somarriba L, Halligan DL, van der Heijden MS, Loriot Y, Rosenberg JE, Fong L, Mellman I, Chen DS, Green M, Derleth C, Fine GD, Hegde PS, Bourgon R, Powles T. Mariathasan S, et al. Among authors: turley sj. Nature. 2018 Feb 22;554(7693):544-548. doi: 10.1038/nature25501. Epub 2018 Feb 14. Nature. 2018. PMID: 29443960 Free PMC article.
Adaptive adipose tissue stromal plasticity in response to cold stress and antibody-based metabolic therapy.
Chang JC, Durinck S, Chen MZ, Martinez-Martin N, Zhang JA, Lehoux I, Li H, Lin M, Wu J, Bainbridge TW, Ernst JA, Ramani SR, Paduchuri S, Kates L, Solon M, Buechler MB, Castiglioni A, Thai M, Breart B, Modrusan Z, Peterson AS, Turley SJ, Sonoda J. Chang JC, et al. Among authors: turley sj. Sci Rep. 2019 Jun 20;9(1):8833. doi: 10.1038/s41598-019-45354-1. Sci Rep. 2019. PMID: 31222070 Free PMC article.
Single-Cell RNA Sequencing Reveals Stromal Evolution into LRRC15+ Myofibroblasts as a Determinant of Patient Response to Cancer Immunotherapy.
Dominguez CX, Müller S, Keerthivasan S, Koeppen H, Hung J, Gierke S, Breart B, Foreman O, Bainbridge TW, Castiglioni A, Senbabaoglu Y, Modrusan Z, Liang Y, Junttila MR, Klijn C, Bourgon R, Turley SJ. Dominguez CX, et al. Among authors: turley sj. Cancer Discov. 2020 Feb;10(2):232-253. doi: 10.1158/2159-8290.CD-19-0644. Epub 2019 Nov 7. Cancer Discov. 2020. PMID: 31699795
Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient.
McCarthy N, Manieri E, Storm EE, Saadatpour A, Luoma AM, Kapoor VN, Madha S, Gaynor LT, Cox C, Keerthivasan S, Wucherpfennig K, Yuan GC, de Sauvage FJ, Turley SJ, Shivdasani RA. McCarthy N, et al. Among authors: turley sj. Cell Stem Cell. 2020 Mar 5;26(3):391-402.e5. doi: 10.1016/j.stem.2020.01.008. Epub 2020 Feb 20. Cell Stem Cell. 2020. PMID: 32084389 Free PMC article.
The Immunoglobulin Superfamily Receptome Defines Cancer-Relevant Networks Associated with Clinical Outcome.
Verschueren E, Husain B, Yuen K, Sun Y, Paduchuri S, Senbabaoglu Y, Lehoux I, Arena TA, Wilson B, Lianoglou S, Bakalarski C, Franke Y, Chan P, Wong AW, Gonzalez LC, Mariathasan S, Turley SJ, Lill JR, Martinez-Martin N. Verschueren E, et al. Among authors: turley sj. Cell. 2020 Jul 23;182(2):329-344.e19. doi: 10.1016/j.cell.2020.06.007. Epub 2020 Jun 25. Cell. 2020. PMID: 32589946 Free article.
Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues.
Kapoor VN, Müller S, Keerthivasan S, Brown M, Chalouni C, Storm EE, Castiglioni A, Lane R, Nitschke M, Dominguez CX, Astarita JL, Krishnamurty AT, Carbone CB, Senbabaoglu Y, Wang AW, Wu X, Cremasco V, Roose-Girma M, Tam L, Doerr J, Chen MZ, Lee WP, Modrusan Z, Yang YA, Bourgon R, Sandoval W, Shaw AS, de Sauvage FJ, Mellman I, Moussion C, Turley SJ. Kapoor VN, et al. Among authors: turley sj. Nat Immunol. 2021 May;22(5):571-585. doi: 10.1038/s41590-021-00920-6. Epub 2021 Apr 26. Nat Immunol. 2021. PMID: 33903764
Homeostatic functions of monocytes and interstitial lung macrophages are regulated via collagen domain-binding receptor LAIR1.
Keerthivasan S, Şenbabaoğlu Y, Martinez-Martin N, Husain B, Verschueren E, Wong A, Yang YA, Sun Y, Pham V, Hinkle T, Oei Y, Madireddi S, Corpuz R, Tam L, Carlisle S, Roose-Girma M, Modrusan Z, Ye Z, Koerber JT, Turley SJ. Keerthivasan S, et al. Among authors: turley sj. Immunity. 2021 Jul 13;54(7):1511-1526.e8. doi: 10.1016/j.immuni.2021.06.012. Immunity. 2021. PMID: 34260887 Free article.
The neutrophil protein CD177 is a novel PDPN receptor that regulates human cancer-associated fibroblast physiology.
Astarita JL, Keerthivasan S, Husain B, Şenbabaoğlu Y, Verschueren E, Gierke S, Pham VC, Peterson SM, Chalouni C, Pierce AA, Lill JR, Gonzalez LC, Martinez-Martin N, Turley SJ. Astarita JL, et al. Among authors: turley sj. PLoS One. 2021 Dec 8;16(12):e0260800. doi: 10.1371/journal.pone.0260800. eCollection 2021. PLoS One. 2021. PMID: 34879110 Free PMC article.
114 results