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Regional Analysis of Intact and Defective HIV Proviruses in the Brain of Viremic and Virally Suppressed People with HIV.
Angelovich TA, Cochrane CR, Zhou J, Tumpach C, Byrnes SJ, Jamal Eddine J, Waring E, Busman-Sahay K, Deleage C, Jenkins TA, Hearps AC, Turville S, Gorry PR, Lewin SR, Brew BJ, Estes JD, Roche M, Churchill MJ. Angelovich TA, et al. Among authors: tumpach c. Ann Neurol. 2023 Oct;94(4):798-802. doi: 10.1002/ana.26750. Epub 2023 Aug 12. Ann Neurol. 2023. PMID: 37493435 Free PMC article.
Human Immunodeficiency Virus (HIV)-Infected CCR6+ Rectal CD4+ T Cells and HIV Persistence On Antiretroviral Therapy.
Anderson JL, Khoury G, Fromentin R, Solomon A, Chomont N, Sinclair E, Milush JM, Hartogensis W, Bacchetti P, Roche M, Tumpach C, Gartner M, Pitman MC, Epling CL, Hoh R, Hecht FM, Somsouk M, Cameron PU, Deeks SG, Lewin SR. Anderson JL, et al. Among authors: tumpach c. J Infect Dis. 2020 Feb 18;221(5):744-755. doi: 10.1093/infdis/jiz509. J Infect Dis. 2020. PMID: 31796951 Free PMC article.
CXCR4-Using HIV Strains Predominate in Naive and Central Memory CD4+ T Cells in People Living with HIV on Antiretroviral Therapy: Implications for How Latency Is Established and Maintained.
Roche M, Tumpach C, Symons J, Gartner M, Anderson JL, Khoury G, Cashin K, Cameron PU, Churchill MJ, Deeks SG, Gorry PR, Lewin SR. Roche M, et al. Among authors: tumpach c. J Virol. 2020 Feb 28;94(6):e01736-19. doi: 10.1128/JVI.01736-19. Print 2020 Feb 28. J Virol. 2020. PMID: 31852784 Free PMC article.
Longitudinal analysis of subtype C envelope tropism for memory CD4+ T cell subsets over the first 3 years of untreated HIV-1 infection.
Gartner MJ, Gorry PR, Tumpach C, Zhou J, Dantanarayana A, Chang JJ, Angelovich TA, Ellenberg P, Laumaea AE, Nonyane M, Moore PL, Lewin SR, Churchill MJ, Flynn JK, Roche M. Gartner MJ, et al. Among authors: tumpach c. Retrovirology. 2020 Aug 6;17(1):24. doi: 10.1186/s12977-020-00532-2. Retrovirology. 2020. PMID: 32762760 Free PMC article.
A clinical trial of non-invasive imaging with an anti-HIV antibody labelled with copper-64 in people living with HIV and uninfected controls.
McMahon JH, Zerbato JM, Lau JSY, Lange JL, Roche M, Tumpach C, Dantanarayana A, Rhodes A, Chang J, Rasmussen TA, Mackenzie CA, Alt K, Hagenauer M, Roney J, O'Bryan J, Carey A, McIntyre R, Beech P, O'Keefe GJ, Wichmann CW, Scott FE, Guo N, Lee ST, Liu Z, Caskey M, Nussenzweig MC, Donnelly PS, Egan G, Hagemeyer CE, Scott AM, Lewin SR. McMahon JH, et al. Among authors: tumpach c. EBioMedicine. 2021 Mar;65:103252. doi: 10.1016/j.ebiom.2021.103252. Epub 2021 Feb 25. EBioMedicine. 2021. PMID: 33640794 Free PMC article. Clinical Trial.
Pembrolizumab induces HIV latency reversal in people living with HIV and cancer on antiretroviral therapy.
Uldrick TS, Adams SV, Fromentin R, Roche M, Fling SP, Gonçalves PH, Lurain K, Ramaswami R, Wang CJ, Gorelick RJ, Welker JL, O'Donoghue L, Choudhary H, Lifson JD, Rasmussen TA, Rhodes A, Tumpach C, Yarchoan R, Maldarelli F, Cheever MA, Sékaly R, Chomont N, Deeks SG, Lewin SR. Uldrick TS, et al. Among authors: tumpach c. Sci Transl Med. 2022 Jan 26;14(629):eabl3836. doi: 10.1126/scitranslmed.abl3836. Epub 2022 Jan 26. Sci Transl Med. 2022. PMID: 35080914 Free PMC article.
Memory CD4+ T cells that co-express PD1 and CTLA4 have reduced response to activating stimuli facilitating HIV latency.
Rasmussen TA, Zerbato JM, Rhodes A, Tumpach C, Dantanarayana A, McMahon JH, Lau JSY, Chang JJ, Gubser C, Brown W, Hoh R, Krone M, Pascoe R, Chiu CY, Bramhall M, Lee HJ, Haque A, Fromentin R, Chomont N, Milush J, Van der Sluis RM, Palmer S, Deeks SG, Cameron PU, Evans V, Lewin SR. Rasmussen TA, et al. Among authors: tumpach c. Cell Rep Med. 2022 Oct 18;3(10):100766. doi: 10.1016/j.xcrm.2022.100766. Epub 2022 Oct 4. Cell Rep Med. 2022. PMID: 36198308 Free PMC article.
HIV DNA persists in hepatocytes in people with HIV-hepatitis B co-infection on antiretroviral therapy.
Zerbato JM, Avihingsanon A, Singh KP, Zhao W, Deleage C, Rosen E, Cottrell ML, Rhodes A, Dantanarayana A, Tumpach C, Tennakoon S, Crane M, Price DJ, Braat S, Mason H, Roche M, Kashuba ADM, Revill PA, Audsley J, Lewin SR. Zerbato JM, et al. Among authors: tumpach c. EBioMedicine. 2023 Jan;87:104391. doi: 10.1016/j.ebiom.2022.104391. Epub 2022 Dec 8. EBioMedicine. 2023. PMID: 36502576 Free PMC article.
Persistence of envelopes in different CD4+ T-cell subsets in antiretroviral therapy-suppressed people with HIV.
Gartner MJ, Tumpach C, Dantanarayana A, Stern J, Zerbato JM, Chang JJ, Angelovich TA, Anderson JL, Symons J, Deeks SG, Flynn JK, Lewin SR, Churchill MJ, Gorry PR, Roche M. Gartner MJ, et al. Among authors: tumpach c. AIDS. 2023 Feb 1;37(2):247-257. doi: 10.1097/QAD.0000000000003424. Epub 2022 Nov 18. AIDS. 2023. PMID: 36541637 Free PMC article.
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