Tumber A - Search Results

1

In vitro selection of macrocyclic peptide inhibitors containing cyclic γ^2,4-amino acids targeting the SARS-CoV-2 main protease.

Miura T, Malla TR, Owen CD, Tumber A, Brewitz L, McDonough MA, Salah E, Terasaka N, Katoh T, Lukacik P, Strain-Damerell C, Mikolajek H, Walsh MA, Kawamura A, Schofield CJ, Suga H. Miura T, et al. Among authors: tumber a. Nat Chem. 2023 Jul;15(7):998-1005. doi: 10.1038/s41557-023-01205-1. Epub 2023 May 22. Nat Chem. 2023. PMID: 37217786 Free PMC article.

2

A series of potent CREBBP bromodomain ligands reveals an induced-fit pocket stabilized by a cation-π interaction.

Rooney TP, Filippakopoulos P, Fedorov O, Picaud S, Cortopassi WA, Hay DA, Martin S, Tumber A, Rogers CM, Philpott M, Wang M, Thompson AL, Heightman TD, Pryde DC, Cook A, Paton RS, Müller S, Knapp S, Brennan PE, Conway SJ. Rooney TP, et al. Among authors: tumber a. Angew Chem Int Ed Engl. 2014 Jun 10;53(24):6126-30. doi: 10.1002/anie.201402750. Epub 2014 May 12. Angew Chem Int Ed Engl. 2014. PMID: 24821300 Free PMC article.

3

Stromelysin (MMP-3) synthesis is up-regulated in estrogen-deficient mouse osteoblasts in vivo and in vitro.

Breckon JJ, Papaioannou S, Kon LW, Tumber A, Hembry RM, Murphy G, Reynolds JJ, Meikle MC. Breckon JJ, et al. Among authors: tumber a. J Bone Miner Res. 1999 Nov;14(11):1880-90. doi: 10.1359/jbmr.1999.14.11.1880. J Bone Miner Res. 1999. PMID: 10571688 Free article.

4

Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors.

Khan N, Jeffers M, Kumar S, Hackett C, Boldog F, Khramtsov N, Qian X, Mills E, Berghs SC, Carey N, Finn PW, Collins LS, Tumber A, Ritchie JW, Jensen PB, Lichenstein HS, Sehested M. Khan N, et al. Among authors: tumber a. Biochem J. 2008 Jan 15;409(2):581-9. doi: 10.1042/BJ20070779. Biochem J. 2008. PMID: 17868033

5

Ceramide-induced cell death/survival in murine osteoblasts.

Hill PA, Tumber A. Hill PA, et al. Among authors: tumber a. J Endocrinol. 2010 Aug;206(2):225-33. doi: 10.1677/JOE-10-0068. Epub 2010 May 13. J Endocrinol. 2010. PMID: 20466846

6

Breast cancer cells induce osteoclast formation by stimulating host IL-11 production and downregulating granulocyte/macrophage colony-stimulating factor.

Morgan H, Tumber A, Hill PA. Morgan H, et al. Among authors: tumber a. Int J Cancer. 2004 May 1;109(5):653-60. doi: 10.1002/ijc.20056. Int J Cancer. 2004. PMID: 14999770 Free article.

7

Novel amide derivatives as inhibitors of histone deacetylase: design, synthesis and SAR.

Andrianov V, Gailite V, Lola D, Loza E, Semenikhina V, Kalvinsh I, Finn P, Petersen KD, Ritchie JW, Khan N, Tumber A, Collins LS, Vadlamudi SM, Björkling F, Sehested M. Andrianov V, et al. Among authors: tumber a. Eur J Med Chem. 2009 Mar;44(3):1067-85. doi: 10.1016/j.ejmech.2008.06.020. Epub 2008 Jun 27. Eur J Med Chem. 2009. PMID: 18672316

8

G-protein signalling pathways and oestrogen: a role of balanced maintenance in osteoblasts.

Papaioannou S, Tumber AM, Meikle MC, McDonald F. Papaioannou S, et al. Among authors: tumber am. Biochim Biophys Acta. 1999 Apr 1;1449(3):284-92. doi: 10.1016/s0167-4889(99)00025-7. Biochim Biophys Acta. 1999. PMID: 10209307 Free article.

9

Multiple extracellular signals promote osteoblast survival and apoptosis.

Hill PA, Tumber A, Meikle MC. Hill PA, et al. Among authors: tumber a. Endocrinology. 1997 Sep;138(9):3849-58. doi: 10.1210/endo.138.9.5370. Endocrinology. 1997. PMID: 9275074

10

Autocrine signals promote osteoblast survival in culture.

Tumber A, Meikle MC, Hill PA. Tumber A, et al. J Endocrinol. 2000 Dec;167(3):383-90. doi: 10.1677/joe.0.1670383. J Endocrinol. 2000. PMID: 11115765

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