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Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors.
Zang J, Peters F, Cambet Y, Cifuentes-Pagano E, Hissabu MMS, Dustin CM, Svensson LH, Olesen MM, Poulsen MFL, Jacobsen S, Tuelung PS, Narayanan D, Langkilde AE, Gajhede M, Pagano PJ, Jaquet V, Vilhardt F, Bach A. Zang J, et al. Among authors: tuelung ps. J Med Chem. 2023 Nov 9;66(21):14963-15005. doi: 10.1021/acs.jmedchem.3c01548. Epub 2023 Oct 19. J Med Chem. 2023. PMID: 37857466
A previously unrecognized superfamily of macro-conotoxins includes an inhibitor of the sensory neuron calcium channel Cav2.3.
Hackney CM, Flórez Salcedo P, Mueller E, Koch TL, Kjelgaard LD, Watkins M, Zachariassen LG, Tuelung PS, McArthur JR, Adams DJ, Kristensen AS, Olivera B, Finol-Urdaneta RK, Safavi-Hemami H, Morth JP, Ellgaard L. Hackney CM, et al. Among authors: tuelung ps. PLoS Biol. 2023 Aug 3;21(8):e3002217. doi: 10.1371/journal.pbio.3002217. eCollection 2023 Aug. PLoS Biol. 2023. PMID: 37535677 Free PMC article.