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Discovery of an Anion-Dependent Farnesyltransferase Inhibitor from a Phenotypic Screen.
Bukhtiyarova M, Cook EM, Hancock PJ, Hruza AW, Shaw AW, Adam GC, Barnard RJO, McKenna PM, Holloway MK, Bell IM, Carroll S, Cornella-Taracido I, Cox CD, Kutchukian PS, Powell DA, Strickland C, Trotter BW, Tudor M, Wolkenberg S, Li J, Tellers DM. Bukhtiyarova M, et al. Among authors: tudor m. ACS Med Chem Lett. 2020 Dec 23;12(1):99-106. doi: 10.1021/acsmedchemlett.0c00551. eCollection 2021 Jan 14. ACS Med Chem Lett. 2020. PMID: 33488970 Free PMC article.
A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells.
Moore KP, Schwaid AG, Tudor M, Park S, Beshore DC, Converso A, Shipe WD, Anand R, Lan P, Moningka R, Rothman DM, Sun W, Chi A, Cornella-Taracido I, Adam GC, Bahnck-Teets C, Carroll SS, Fay JF, Goh SL, Lusen J, Quan S, Rodriguez S, Xu M, Andrews CL, Song C, Filzen T, Li J, Hollenstein K, Klein DJ, Lammens A, Lim UM, Fang Z, McHale C, Li Y, Lu M, Diamond TL, Howell BJ, Zuck P, Balibar CJ. Moore KP, et al. Among authors: tudor m. ACS Chem Biol. 2022 Sep 16;17(9):2595-2604. doi: 10.1021/acschembio.2c00515. Epub 2022 Aug 31. ACS Chem Biol. 2022. PMID: 36044633
High-Content Reporter Assays.
Cook E, Hermes J, Li J, Tudor M. Cook E, et al. Among authors: tudor m. Methods Mol Biol. 2018;1755:179-195. doi: 10.1007/978-1-4939-7724-6_13. Methods Mol Biol. 2018. PMID: 29671271
Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Nav1.7 for the Treatment of Pain.
Adams GL, Pall PS, Grauer SM, Zhou X, Ballard JE, Vavrek M, Kraus RL, Morissette P, Li N, Colarusso S, Bianchi E, Palani A, Klein R, John CT, Wang D, Tudor M, Nolting AF, Biba M, Nowak T, Makarov AA, Reibarkh M, Buevich AV, Zhong W, Regalado EL, Wang X, Gao Q, Shahripour A, Zhu Y, de Simone D, Frattarelli T, Pasquini NM, Magotti P, Iaccarino R, Li Y, Solly K, Lee KJ, Wang W, Chen F, Zeng H, Wang J, Regan H, Amin RP, Regan CP, Burgey CS, Henze DA, Sun C, Tellers DM. Adams GL, et al. Among authors: tudor m. J Med Chem. 2022 Jan 13;65(1):485-496. doi: 10.1021/acs.jmedchem.1c01570. Epub 2021 Dec 21. J Med Chem. 2022. PMID: 34931831
Translatability: what does it mean in drug discovery?
Tudor M, Hermes J, Li J. Tudor M, et al. Drug Discov Today. 2016 Jun;21(6):865-7. doi: 10.1016/j.drudis.2016.03.010. Epub 2016 Mar 26. Drug Discov Today. 2016. PMID: 27021791 No abstract available.
Endogenous Locus Reporter Assays.
Liu Y, Hermes J, Li J, Tudor M. Liu Y, et al. Among authors: tudor m. Methods Mol Biol. 2018;1755:163-177. doi: 10.1007/978-1-4939-7724-6_12. Methods Mol Biol. 2018. PMID: 29671270
Parsimonious discovery of synergistic drug combinations.
Severyn B, Liehr RA, Wolicki A, Nguyen KH, Hudak EM, Ferrer M, Caldwell JS, Hermes JD, Li J, Tudor M. Severyn B, et al. Among authors: tudor m. ACS Chem Biol. 2011 Dec 16;6(12):1391-8. doi: 10.1021/cb2003225. Epub 2011 Oct 19. ACS Chem Biol. 2011. PMID: 21974780
Development of a High-Throughput Gene Expression Screen for Modulators of RAS-MAPK Signaling in a Mutant RAS Cellular Context.
Severyn B, Nguyen T, Altman MD, Li L, Nagashima K, Naumov GN, Sathyanarayanan S, Cook E, Morris E, Ferrer M, Arthur B, Benita Y, Watters J, Loboda A, Hermes J, Gilliland DG, Cleary MA, Carroll PM, Strack P, Tudor M, Andersen JN. Severyn B, et al. Among authors: tudor m. J Biomol Screen. 2016 Oct;21(9):989-97. doi: 10.1177/1087057116658646. Epub 2016 Jul 26. J Biomol Screen. 2016. PMID: 27461835
117 results