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Structural basis for proton coupled cystine transport by cystinosin.
Löbel M, Salphati SP, El Omari K, Wagner A, Tucker SJ, Parker JL, Newstead S. Löbel M, et al. Among authors: tucker sj. Nat Commun. 2022 Aug 17;13(1):4845. doi: 10.1038/s41467-022-32589-2. Nat Commun. 2022. PMID: 35977944 Free PMC article.
Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation.
Rödström KEJ, Cloake A, Sörmann J, Baronina A, Smith KHM, Pike ACW, Ang J, Proks P, Schewe M, Holland-Kaye I, Bushell SR, Elliott J, Pardon E, Baukrowitz T, Owens RJ, Newstead S, Steyaert J, Carpenter EP, Tucker SJ. Rödström KEJ, et al. Among authors: tucker sj. Nat Commun. 2024 May 16;15(1):4173. doi: 10.1038/s41467-024-48536-2. Nat Commun. 2024. PMID: 38755204 Free PMC article.
A lower X-gate in TASK channels traps inhibitors within the vestibule.
Rödström KEJ, Kiper AK, Zhang W, Rinné S, Pike ACW, Goldstein M, Conrad LJ, Delbeck M, Hahn MG, Meier H, Platzk M, Quigley A, Speedman D, Shrestha L, Mukhopadhyay SMM, Burgess-Brown NA, Tucker SJ, Müller T, Decher N, Carpenter EP. Rödström KEJ, et al. Among authors: tucker sj. Nature. 2020 Jun;582(7812):443-447. doi: 10.1038/s41586-020-2250-8. Epub 2020 Apr 29. Nature. 2020. PMID: 32499642
Gain-of-function mutations in KCNK3 cause a developmental disorder with sleep apnea.
Sörmann J, Schewe M, Proks P, Jouen-Tachoire T, Rao S, Riel EB, Agre KE, Begtrup A, Dean J, Descartes M, Fischer J, Gardham A, Lahner C, Mark PR, Muppidi S, Pichurin PN, Porrmann J, Schallner J, Smith K, Straub V, Vasudevan P, Willaert R, Carpenter EP, Rödström KEJ, Hahn MG, Müller T, Baukrowitz T, Hurles ME, Wright CF, Tucker SJ. Sörmann J, et al. Among authors: tucker sj. Nat Genet. 2022 Oct;54(10):1534-1543. doi: 10.1038/s41588-022-01185-x. Epub 2022 Oct 4. Nat Genet. 2022. PMID: 36195757 Free PMC article.
Structure and assembly of calcium homeostasis modulator proteins.
Syrjanen JL, Michalski K, Chou TH, Grant T, Rao S, Simorowski N, Tucker SJ, Grigorieff N, Furukawa H. Syrjanen JL, et al. Among authors: tucker sj. Nat Struct Mol Biol. 2020 Feb;27(2):150-159. doi: 10.1038/s41594-019-0369-9. Epub 2020 Jan 27. Nat Struct Mol Biol. 2020. PMID: 31988524 Free PMC article.
233 results