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Antitumor Reactive T-Cell Responses Are Enhanced In Vivo by DAMP Prothymosin Alpha and Its C-Terminal Decapeptide.
Birmpilis AI, Karachaliou CE, Samara P, Ioannou K, Selemenakis P, Kostopoulos IV, Kavrochorianou N, Kalbacher H, Livaniou E, Haralambous S, Kotsinas A, Farzaneh F, Trougakos IP, Voelter W, Dimopoulos MA, Bamias A, Tsitsilonis O. Birmpilis AI, et al. Among authors: tsitsilonis o. Cancers (Basel). 2019 Nov 9;11(11):1764. doi: 10.3390/cancers11111764. Cancers (Basel). 2019. PMID: 31717548 Free PMC article.
The immunologically active site of prothymosin alpha is located at the carboxy-terminus of the polypeptide. Evaluation of its in vitro effects in cancer patients.
Skopeliti M, Voutsas IF, Klimentzou P, Tsiatas ML, Beck A, Bamias A, Moraki M, Livaniou E, Neagu M, Voelter W, Tsitsilonis OE. Skopeliti M, et al. Cancer Immunol Immunother. 2006 Oct;55(10):1247-57. doi: 10.1007/s00262-005-0108-4. Epub 2006 Feb 2. Cancer Immunol Immunother. 2006. PMID: 16453152 Free PMC article.
Significant differences of lymphocytes isolated from ascites of patients with ovarian cancer compared to blood and tumor lymphocytes. Association of CD3+CD56+ cells with platinum resistance.
Bamias A, Tsiatas ML, Kafantari E, Liakou C, Rodolakis A, Voulgaris Z, Vlahos G, Papageorgiou T, Tsitsilonis O, Bamia C, Papatheodoridis G, Politi E, Archimandritis A, Antsaklis A, Dimopoulos MA. Bamias A, et al. Among authors: tsitsilonis o. Gynecol Oncol. 2007 Jul;106(1):75-81. doi: 10.1016/j.ygyno.2007.02.029. Epub 2007 Apr 11. Gynecol Oncol. 2007. PMID: 17433425
Correlation of NK T-like CD3+CD56+ cells and CD4+CD25+(hi) regulatory T cells with VEGF and TNFalpha in ascites from advanced ovarian cancer: Association with platinum resistance and prognosis in patients receiving first-line, platinum-based chemotherapy.
Bamias A, Koutsoukou V, Terpos E, Tsiatas ML, Liakos C, Tsitsilonis O, Rodolakis A, Voulgaris Z, Vlahos G, Papageorgiou T, Papatheodoridis G, Archimandritis A, Antsaklis A, Dimopoulos MA. Bamias A, et al. Among authors: tsitsilonis o. Gynecol Oncol. 2008 Feb;108(2):421-7. doi: 10.1016/j.ygyno.2007.10.018. Epub 2007 Nov 26. Gynecol Oncol. 2008. PMID: 18036640
Prothymosin alpha immunoactive carboxyl-terminal peptide TKKQKTDEDD stimulates lymphocyte reactions, induces dendritic cell maturation and adopts a beta-sheet conformation in a sequence-specific manner.
Skopeliti M, Iconomidou VA, Derhovanessian E, Pawelec G, Voelter W, Kalbacher H, Hamodrakas SJ, Tsitsilonis OE. Skopeliti M, et al. Mol Immunol. 2009 Feb;46(5):784-92. doi: 10.1016/j.molimm.2008.09.014. Epub 2008 Oct 30. Mol Immunol. 2009. PMID: 18976813
108 results