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Clinical utility of whole-genome DNA methylation profiling as a primary molecular diagnostic assay for central nervous system tumors-A prospective study and guidelines for clinical testing.
Galbraith K, Vasudevaraja V, Serrano J, Shen G, Tran I, Abdallat N, Wen M, Patel S, Movahed-Ezazi M, Faustin A, Spino-Keeton M, Roberts LG, Maloku E, Drexler SA, Liechty BL, Pisapia D, Krasnozhen-Ratush O, Rosenblum M, Shroff S, Boué DR, Davidson C, Mao Q, Suchi M, North P, Hopp A, Segura A, Jarzembowski JA, Parsons L, Johnson MD, Mobley B, Samore W, McGuone D, Gopal PP, Canoll PD, Horbinski C, Fullmer JM, Farooqui MS, Gokden M, Wadhwani NR, Richardson TE, Umphlett M, Tsankova NM, DeWitt JC, Sen C, Placantonakis DG, Pacione D, Wisoff JH, Teresa Hidalgo E, Harter D, William CM, Cordova C, Kurz SC, Barbaro M, Orringer DA, Karajannis MA, Sulman EP, Gardner SL, Zagzag D, Tsirigos A, Allen JC, Golfinos JG, Snuderl M. Galbraith K, et al. Among authors: tsirigos a. Neurooncol Adv. 2023 Jun 26;5(1):vdad076. doi: 10.1093/noajnl/vdad076. eCollection 2023 Jan-Dec. Neurooncol Adv. 2023. PMID: 37476329 Free PMC article.
SETD2 mutations do not contribute to clonal fitness in response to chemotherapy in childhood B cell acute lymphoblastic leukemia.
Contreras Yametti GP, Robbins G, Chowdhury A, Narang S, Ostrow TH, Kilberg H, Greenberg J, Kramer L, Raetz E, Tsirigos A, Evensen NA, Carroll WL. Contreras Yametti GP, et al. Among authors: tsirigos a. Leuk Lymphoma. 2024 Jan;65(1):78-90. doi: 10.1080/10428194.2023.2273752. Epub 2024 Jan 10. Leuk Lymphoma. 2024. PMID: 37874744
Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation.
Tiniakou I, Hsu PF, Lopez-Zepeda LS, Garipler G, Esteva E, Adams NM, Jang G, Soni C, Lau CM, Liu F, Khodadadi-Jamayran A, Rodrick TC, Jones D, Tsirigos A, Ohler U, Bedford MT, Nimer SD, Kaartinen V, Mazzoni EO, Reizis B. Tiniakou I, et al. Among authors: tsirigos a. Sci Immunol. 2024 Apr 12;9(94):eadi1023. doi: 10.1126/sciimmunol.adi1023. Epub 2024 Apr 12. Sci Immunol. 2024. PMID: 38608038
Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer.
Pillai R, LeBoeuf SE, Hao Y, New C, Blum JLE, Rashidfarrokhi A, Huang SM, Bahamon C, Wu WL, Karadal-Ferrena B, Herrera A, Ivanova E, Cross M, Bossowski JP, Ding H, Hayashi M, Rajalingam S, Karakousi T, Sayin VI, Khanna KM, Wong KK, Wild R, Tsirigos A, Poirier JT, Rudin CM, Davidson SM, Koralov SB, Papagiannakopoulos T. Pillai R, et al. Among authors: tsirigos a. Sci Adv. 2024 Mar 29;10(13):eadm9859. doi: 10.1126/sciadv.adm9859. Epub 2024 Mar 27. Sci Adv. 2024. PMID: 38536921 Free PMC article.
Self-supervised artificial intelligence predicts recurrence, metastasis and disease specific death from primary cutaneous squamous cell carcinoma at diagnosis.
Coudray N, Juarez MC, Criscito MC, Quiros AC, Wilken R, Cullison SRJ, Stevenson ML, Doudican NA, Yuan K, Aquino JD, Klufas DM, North JP, Yu SS, Murad F, Ruiz E, Schmults CD, Tsirigos A, Carucci JA. Coudray N, et al. Among authors: tsirigos a. Res Sq [Preprint]. 2023 Dec 13:rs.3.rs-3607399. doi: 10.21203/rs.3.rs-3607399/v1. Res Sq. 2023. PMID: 38168253 Free PMC article. Preprint.
3D Enhancer-promoter networks provide predictive features for gene expression and coregulation in early embryonic lineages.
Murphy D, Salataj E, Di Giammartino DC, Rodriguez-Hernaez J, Kloetgen A, Garg V, Char E, Uyehara CM, Ee LS, Lee U, Stadtfeld M, Hadjantonakis AK, Tsirigos A, Polyzos A, Apostolou E. Murphy D, et al. Among authors: tsirigos a. Nat Struct Mol Biol. 2024 Jan;31(1):125-140. doi: 10.1038/s41594-023-01130-4. Epub 2023 Dec 5. Nat Struct Mol Biol. 2024. PMID: 38053013
The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability.
Ravn-Boess N, Roy N, Hattori T, Bready D, Donaldson H, Lawson C, Lapierre C, Korman A, Rodrick T, Liu E, Frenster JD, Stephan G, Wilcox J, Corrado AD, Cai J, Ronnen R, Wang S, Haddock S, Sabio Ortiz J, Mishkit O, Khodadadi-Jamayran A, Tsirigos A, Fenyö D, Zagzag D, Drube J, Hoffmann C, Perna F, Jones DR, Possemato R, Koide A, Koide S, Park CY, Placantonakis DG. Ravn-Boess N, et al. Among authors: tsirigos a. Cell Rep. 2023 Nov 28;42(11):113374. doi: 10.1016/j.celrep.2023.113374. Epub 2023 Nov 8. Cell Rep. 2023. PMID: 37938973 Free PMC article.
174 results