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Discovery of novel stem cell mobilizers that target the CXCR4 receptor.
Wu CH, Chang CP, Song JS, Jan JJ, Chou MC, Wu SH, Yeh KC, Wong YC, Hsieh CJ, Chen CT, Kao TT, Wu SY, Yeh CF, Tseng CT, Chao YS, Shia KS. Wu CH, et al. Among authors: tseng ct. ChemMedChem. 2012 Feb 6;7(2):209-12. doi: 10.1002/cmdc.201100525. Epub 2011 Dec 20. ChemMedChem. 2012. PMID: 22190478 No abstract available.
Discovery of 1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced obese mice.
Chang CP, Wu CH, Song JS, Chou MC, Wong YC, Lin Y, Yeh TK, Sadani AA, Ou MH, Chen KH, Chen PH, Kuo PC, Tseng CT, Chang KH, Tseng SL, Chao YS, Hung MS, Shia KS. Chang CP, et al. Among authors: tseng sl, tseng ct. J Med Chem. 2013 Dec 27;56(24):9920-33. doi: 10.1021/jm401158e. Epub 2013 Dec 4. J Med Chem. 2013. PMID: 24224693
Bromomethylthioindole Inspired Carbazole Hybrids as Promising Class of Anti-MRSA Agents.
Cheng CY, Chang CP, Lauderdale TY, Yu GY, Lee JC, Jhang YW, Wu CH, Ke YY, Sadani AA, Yeh CF, Huang IW, Kuo YP, Tsai DJ, Yeh TK, Tseng CT, Song JS, Liu YW, Tsou LK, Shia KS. Cheng CY, et al. Among authors: tseng ct. ACS Med Chem Lett. 2016 Oct 21;7(12):1191-1196. doi: 10.1021/acsmedchemlett.6b00289. eCollection 2016 Dec 8. ACS Med Chem Lett. 2016. PMID: 27994762 Free PMC article.
Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1.
Peng YH, Ueng SH, Tseng CT, Hung MS, Song JS, Wu JS, Liao FY, Fan YS, Wu MH, Hsiao WC, Hsueh CC, Lin SY, Cheng CY, Tu CH, Lee LC, Cheng MF, Shia KS, Shih C, Wu SY. Peng YH, et al. Among authors: tseng ct. J Med Chem. 2016 Jan 14;59(1):282-93. doi: 10.1021/acs.jmedchem.5b01390. Epub 2015 Dec 21. J Med Chem. 2016. PMID: 26642377
Unique Sulfur-Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors.
Peng YH, Liao FY, Tseng CT, Kuppusamy R, Li AS, Chen CH, Fan YS, Wang SY, Wu MH, Hsueh CC, Chang JY, Lee LC, Shih C, Shia KS, Yeh TK, Hung MS, Kuo CC, Song JS, Wu SY, Ueng SH. Peng YH, et al. Among authors: tseng ct. J Med Chem. 2020 Feb 27;63(4):1642-1659. doi: 10.1021/acs.jmedchem.9b01549. Epub 2020 Feb 10. J Med Chem. 2020. PMID: 31961685
157 results