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Candidalysins Are a New Family of Cytolytic Fungal Peptide Toxins.
Richardson JP, Brown R, Kichik N, Lee S, Priest E, Mogavero S, Maufrais C, Wickramasinghe DN, Tsavou A, Kotowicz NK, Hepworth OW, Gallego-Cortés A, Ponde NO, Ho J, Moyes DL, Wilson D, D'Enfert C, Hube B, Naglik JR. Richardson JP, et al. Among authors: tsavou a. mBio. 2022 Feb 22;13(1):e0351021. doi: 10.1128/mbio.03510-21. Epub 2022 Jan 25. mBio. 2022. PMID: 35073742 Free PMC article.
Candida albicans translocation through the intestinal epithelial barrier is promoted by fungal zinc acquisition and limited by NFκB-mediated barrier protection.
Sprague JL, Schille TB, Allert S, Trümper V, Lier A, Großmann P, Priest EL, Tsavou A, Panagiotou G, Naglik JR, Wilson D, Schäuble S, Kasper L, Hube B. Sprague JL, et al. Among authors: tsavou a. PLoS Pathog. 2024 Mar 1;20(3):e1012031. doi: 10.1371/journal.ppat.1012031. eCollection 2024 Mar. PLoS Pathog. 2024. PMID: 38427950 Free PMC article.
Nanobody-mediated neutralization of candidalysin prevents epithelial damage and inflammatory responses that drive vulvovaginal candidiasis pathogenesis.
Valentine M, Rudolph P, Dietschmann A, Tsavou A, Mogavero S, Lee S, Priest EL, Zhurgenbayeva G, Jablonowski N, Timme S, Eggeling C, Allert S, Dolk E, Naglik JR, Figge MT, Gresnigt MS, Hube B. Valentine M, et al. Among authors: tsavou a. mBio. 2024 Mar 13;15(3):e0340923. doi: 10.1128/mbio.03409-23. Epub 2024 Feb 13. mBio. 2024. PMID: 38349176 Free PMC article.