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GDF15 promotes weight loss by enhancing energy expenditure in muscle.
Wang D, Townsend LK, DesOrmeaux GJ, Frangos SM, Batchuluun B, Dumont L, Kuhre RE, Ahmadi E, Hu S, Rebalka IA, Gautam J, Jabile MJT, Pileggi CA, Rehal S, Desjardins EM, Tsakiridis EE, Lally JSV, Juracic ES, Tupling AR, Gerstein HC, Paré G, Tsakiridis T, Harper ME, Hawke TJ, Speakman JR, Blondin DP, Holloway GP, Jørgensen SB, Steinberg GR. Wang D, et al. Among authors: tsakiridis t. Nature. 2023 Jul;619(7968):143-150. doi: 10.1038/s41586-023-06249-4. Epub 2023 Jun 28. Nature. 2023. PMID: 37380764 Free PMC article.
AMPK β1 reduces tumor progression and improves survival in p53 null mice.
Houde VP, Donzelli S, Sacconi A, Galic S, Hammill JA, Bramson JL, Foster RA, Tsakiridis T, Kemp BE, Grasso G, Blandino G, Muti P, Steinberg GR. Houde VP, et al. Among authors: tsakiridis t. Mol Oncol. 2017 Sep;11(9):1143-1155. doi: 10.1002/1878-0261.12079. Epub 2017 Jun 28. Mol Oncol. 2017. PMID: 28544264 Free PMC article.
Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials.
Troncone M, Cargnelli SM, Villani LA, Isfahanian N, Broadfield LA, Zychla L, Wright J, Pond G, Steinberg GR, Tsakiridis T. Troncone M, et al. Among authors: tsakiridis t. Oncotarget. 2017 Apr 27;8(34):57733-57754. doi: 10.18632/oncotarget.17496. eCollection 2017 Aug 22. Oncotarget. 2017. PMID: 28915708 Free PMC article. Review.
Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma.
Lally JSV, Ghoshal S, DePeralta DK, Moaven O, Wei L, Masia R, Erstad DJ, Fujiwara N, Leong V, Houde VP, Anagnostopoulos AE, Wang A, Broadfield LA, Ford RJ, Foster RA, Bates J, Sun H, Wang T, Liu H, Ray AS, Saha AK, Greenwood J, Bhat S, Harriman G, Miao W, Rocnik JL, Westlin WF, Muti P, Tsakiridis T, Harwood HJ Jr, Kapeller R, Hoshida Y, Tanabe KK, Steinberg GR, Fuchs BC. Lally JSV, et al. Among authors: tsakiridis t. Cell Metab. 2019 Jan 8;29(1):174-182.e5. doi: 10.1016/j.cmet.2018.08.020. Epub 2018 Sep 20. Cell Metab. 2019. PMID: 30244972 Free PMC article.
Salicylate enhances the response of prostate cancer to radiotherapy.
Broadfield LA, Marcinko K, Tsakiridis E, Zacharidis PG, Villani L, Lally JSV, Menjolian G, Maharaj D, Mathurin T, Smoke M, Farrell T, Muti P, Steinberg GR, Tsakiridis T. Broadfield LA, et al. Among authors: tsakiridis t, tsakiridis e. Prostate. 2019 Apr;79(5):489-497. doi: 10.1002/pros.23755. Epub 2019 Jan 4. Prostate. 2019. PMID: 30609074
Combined metformin-salicylate treatment provides improved anti-tumor activity and enhanced radiotherapy response in prostate cancer; drug synergy at clinically relevant doses.
Tsakiridis EE, Broadfield L, Marcinko K, Biziotis OD, Ali A, Mekhaeil B, Ahmadi E, Singh K, Mesci A, Zacharidis PG, Anagnostopoulos AE, Berg T, Muti P, Steinberg GR, Tsakiridis T. Tsakiridis EE, et al. Among authors: tsakiridis t. Transl Oncol. 2021 Nov;14(11):101209. doi: 10.1016/j.tranon.2021.101209. Epub 2021 Aug 31. Transl Oncol. 2021. PMID: 34479029 Free PMC article.
70 results