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Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo.
Kaoud TS, Johnson WH, Ebelt ND, Piserchio A, Zamora-Olivares D, Van Ravenstein SX, Pridgen JR, Edupuganti R, Sammons R, Cano M, Warthaka M, Harger M, Tavares CDJ, Park J, Radwan MF, Ren P, Anslyn EV, Tsai KY, Ghose R, Dalby KN. Kaoud TS, et al. Among authors: tsai ky. Nat Commun. 2019 Nov 19;10(1):5232. doi: 10.1038/s41467-019-12996-8. Nat Commun. 2019. PMID: 31745079 Free PMC article.
BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling.
Vin H, Ojeda SS, Ching G, Leung ML, Chitsazzadeh V, Dwyer DW, Adelmann CH, Restrepo M, Richards KN, Stewart LR, Du L, Ferguson SB, Chakravarti D, Ehrenreiter K, Baccarini M, Ruggieri R, Curry JL, Kim KB, Ciurea AM, Duvic M, Prieto VG, Ullrich SE, Dalby KN, Flores ER, Tsai KY. Vin H, et al. Among authors: tsai ky. Elife. 2013 Nov 5;2:e00969. doi: 10.7554/eLife.00969. Elife. 2013. PMID: 24192036 Free PMC article.
JNK2 Is Required for the Tumorigenic Properties of Melanoma Cells.
Du L, Anderson A, Nguyen K, Ojeda SS, Ortiz-Rivera I, Nguyen TN, Zhang T, Kaoud TS, Gray NS, Dalby KN, Tsai KY. Du L, et al. Among authors: tsai ky. ACS Chem Biol. 2019 Jul 19;14(7):1426-1435. doi: 10.1021/acschembio.9b00083. Epub 2019 May 17. ACS Chem Biol. 2019. PMID: 31063355 Free PMC article.
Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation.
Napoli M, Li X, Ackerman HD, Deshpande AA, Barannikov I, Pisegna MA, Bedrosian I, Mitsch J, Quinlan P, Thompson A, Rajapakshe K, Coarfa C, Gunaratne PH, Marchion DC, Magliocco AM, Tsai KY, Flores ER. Napoli M, et al. Among authors: tsai ky. Nat Commun. 2020 Oct 14;11(1):5156. doi: 10.1038/s41467-020-18973-w. Nat Commun. 2020. PMID: 33056990 Free PMC article.
Role for the p53 homologue p73 in E2F-1-induced apoptosis.
Irwin M, Marin MC, Phillips AC, Seelan RS, Smith DI, Liu W, Flores ER, Tsai KY, Jacks T, Vousden KH, Kaelin WG Jr. Irwin M, et al. Among authors: tsai ky. Nature. 2000 Oct 5;407(6804):645-8. doi: 10.1038/35036614. Nature. 2000. PMID: 11034215
Sorafenib suppresses JNK-dependent apoptosis through inhibition of ZAK.
Vin H, Ching G, Ojeda SS, Adelmann CH, Chitsazzadeh V, Dwyer DW, Ma H, Ehrenreiter K, Baccarini M, Ruggieri R, Curry JL, Ciurea AM, Duvic M, Busaidy NL, Tannir NM, Tsai KY. Vin H, et al. Among authors: tsai ky. Mol Cancer Ther. 2014 Jan;13(1):221-9. doi: 10.1158/1535-7163.MCT-13-0561. Epub 2013 Oct 29. Mol Cancer Ther. 2014. PMID: 24170769 Free PMC article.
238 results