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Mitochondrially targeted tamoxifen as anticancer therapy: case series of patients with renal cell carcinoma treated in a phase I/Ib clinical trial.
Bielcikova Z, Werner L, Stursa J, Cerny V, Krizova L, Spacek J, Hlousek S, Vocka M, Bartosova O, Pesta M, Kolostova K, Klezl P, Bobek V, Truksa J, Stemberkova-Hubackova S, Petruzelka L, Michalek P, Neuzil J. Bielcikova Z, et al. Among authors: truksa j. Ther Adv Med Oncol. 2023 Sep 30;15:17588359231197957. doi: 10.1177/17588359231197957. eCollection 2023. Ther Adv Med Oncol. 2023. PMID: 37786538 Free PMC article.
Chelation of Mitochondrial Iron as an Antiparasitic Strategy.
Arbon D, Mach J, Čadková A, Sipkova A, Stursa J, Klanicová K, Machado M, Ganter M, Levytska V, Sojka D, Truksa J, Werner L, Sutak R. Arbon D, et al. Among authors: truksa j. ACS Infect Dis. 2024 Feb 9;10(2):676-687. doi: 10.1021/acsinfecdis.3c00529. Epub 2024 Jan 30. ACS Infect Dis. 2024. PMID: 38287902 Free PMC article.
Anticancer regimens containing third generation taxanes SB-T-121605 and SB-T-121606 are highly effective in resistant ovarian carcinoma model.
Seborova K, Koucka K, Spalenkova A, Holy P, Ehrlichova M, Sychra T, Chen L, Bendale H, Ojima I, Sandoval-Acuña C, Truksa J, Soucek P, Vaclavikova R. Seborova K, et al. Among authors: truksa j. Front Pharmacol. 2022 Nov 9;13:971905. doi: 10.3389/fphar.2022.971905. eCollection 2022. Front Pharmacol. 2022. PMID: 36438837 Free PMC article.
Third-generation taxanes SB-T-121605 and SB-T-121606 are effective in pancreatic ductal adenocarcinoma.
Sychra T, Spalenkova A, Balatka S, Vaclavikova R, Seborova K, Ehrlichova M, Truksa J, Sandoval-Acuña C, Nemcova V, Szabo A, Koci K, Tesarova T, Chen L, Ojima I, Oliverius M, Soucek P. Sychra T, et al. Among authors: truksa j. iScience. 2024 Jan 26;27(2):109044. doi: 10.1016/j.isci.2024.109044. eCollection 2024 Feb 16. iScience. 2024. PMID: 38357661 Free PMC article.
Targeting Mitochondrial Iron Metabolism Suppresses Tumor Growth and Metastasis by Inducing Mitochondrial Dysfunction and Mitophagy.
Sandoval-Acuña C, Torrealba N, Tomkova V, Jadhav SB, Blazkova K, Merta L, Lettlova S, Adamcová MK, Rosel D, Brábek J, Neuzil J, Stursa J, Werner L, Truksa J. Sandoval-Acuña C, et al. Among authors: truksa j. Cancer Res. 2021 May 1;81(9):2289-2303. doi: 10.1158/0008-5472.CAN-20-1628. Epub 2021 Mar 8. Cancer Res. 2021. PMID: 33685989
Complex Mitochondrial Dysfunction Induced by TPP+-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells.
Fuentes-Retamal S, Sandoval-Acuña C, Peredo-Silva L, Guzmán-Rivera D, Pavani M, Torrealba N, Truksa J, Castro-Castillo V, Catalán M, Kemmerling U, Urra FA, Ferreira J. Fuentes-Retamal S, et al. Among authors: truksa j. Cells. 2020 Feb 11;9(2):407. doi: 10.3390/cells9020407. Cells. 2020. PMID: 32053908 Free PMC article.
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