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Loss of Kmt2c in vivo leads to EMT, mitochondrial dysfunction and improved response to lapatinib in breast cancer.
Simigdala N, Chalari A, Sklirou AD, Chavdoula E, Papafotiou G, Melissa P, Kafalidou A, Paschalidis N, Pateras IS, Athanasiadis E, Konstantopoulos D, Trougakos IP, Klinakis A. Simigdala N, et al. Among authors: trougakos ip. Cell Mol Life Sci. 2023 Mar 18;80(4):100. doi: 10.1007/s00018-023-04734-7. Cell Mol Life Sci. 2023. PMID: 36933062 Free PMC article.
The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis.
Evangelou K, Bartkova J, Kotsinas A, Pateras IS, Liontos M, Velimezi G, Kosar M, Liloglou T, Trougakos IP, Dyrskjot L, Andersen CL, Papaioannou M, Drosos Y, Papafotiou G, Hodny Z, Sosa-Pineda B, Wu XR, Klinakis A, Ørntoft T, Lukas J, Bartek J, Gorgoulis VG. Evangelou K, et al. Among authors: trougakos ip. Cell Death Differ. 2013 Nov;20(11):1485-97. doi: 10.1038/cdd.2013.76. Epub 2013 Jul 12. Cell Death Differ. 2013. PMID: 23852374 Free PMC article.
Cancer chemoprevention via activation of proteostatic modules.
Sklirou A, Papanagnou ED, Fokialakis N, Trougakos IP. Sklirou A, et al. Among authors: trougakos ip. Cancer Lett. 2018 Jan 28;413:110-121. doi: 10.1016/j.canlet.2017.10.034. Epub 2017 Oct 26. Cancer Lett. 2018. PMID: 29107114 Review.
A prototypical non-malignant epithelial model to study genome dynamics and concurrently monitor micro-RNAs and proteins in situ during oncogene-induced senescence.
Komseli ES, Pateras IS, Krejsgaard T, Stawiski K, Rizou SV, Polyzos A, Roumelioti FM, Chiourea M, Mourkioti I, Paparouna E, Zampetidis CP, Gumeni S, Trougakos IP, Pefani DE, O'Neill E, Gagos S, Eliopoulos AG, Fendler W, Chowdhury D, Bartek J, Gorgoulis VG. Komseli ES, et al. Among authors: trougakos ip. BMC Genomics. 2018 Jan 10;19(1):37. doi: 10.1186/s12864-017-4375-1. BMC Genomics. 2018. PMID: 29321003 Free PMC article.
Molecular mechanisms of carfilzomib-induced cardiotoxicity in mice and the emerging cardioprotective role of metformin.
Efentakis P, Kremastiotis G, Varela A, Nikolaou PE, Papanagnou ED, Davos CH, Tsoumani M, Agrogiannis G, Konstantinidou A, Kastritis E, Kanaki Z, Iliodromitis EK, Klinakis A, Dimopoulos MA, Trougakos IP, Andreadou I, Terpos E. Efentakis P, et al. Among authors: trougakos ip. Blood. 2019 Feb 14;133(7):710-723. doi: 10.1182/blood-2018-06-858415. Epub 2018 Nov 27. Blood. 2019. PMID: 30482794 Free article.
195 results