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Exploring and exploiting the systemic effects of deregulated replication licensing.
Petrakis TG, Komseli ES, Papaioannou M, Vougas K, Polyzos A, Myrianthopoulos V, Mikros E, Trougakos IP, Thanos D, Branzei D, Townsend P, Gorgoulis VG. Petrakis TG, et al. Among authors: trougakos ip. Semin Cancer Biol. 2016 Jun;37-38:3-15. doi: 10.1016/j.semcancer.2015.12.002. Epub 2015 Dec 17. Semin Cancer Biol. 2016. PMID: 26707000 Review.
Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins.
Sideridou M, Zakopoulou R, Evangelou K, Liontos M, Kotsinas A, Rampakakis E, Gagos S, Kahata K, Grabusic K, Gkouskou K, Trougakos IP, Kolettas E, Georgakilas AG, Volarevic S, Eliopoulos AG, Zannis-Hadjopoulos M, Moustakas A, Gorgoulis VG. Sideridou M, et al. Among authors: trougakos ip. J Cell Biol. 2011 Dec 26;195(7):1123-40. doi: 10.1083/jcb.201108121. J Cell Biol. 2011. PMID: 22201124 Free PMC article.
Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues.
Georgakopoulou EA, Tsimaratou K, Evangelou K, Fernandez Marcos PJ, Zoumpourlis V, Trougakos IP, Kletsas D, Bartek J, Serrano M, Gorgoulis VG. Georgakopoulou EA, et al. Among authors: trougakos ip. Aging (Albany NY). 2013 Jan;5(1):37-50. doi: 10.18632/aging.100527. Aging (Albany NY). 2013. PMID: 23449538 Free PMC article.
The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis.
Evangelou K, Bartkova J, Kotsinas A, Pateras IS, Liontos M, Velimezi G, Kosar M, Liloglou T, Trougakos IP, Dyrskjot L, Andersen CL, Papaioannou M, Drosos Y, Papafotiou G, Hodny Z, Sosa-Pineda B, Wu XR, Klinakis A, Ørntoft T, Lukas J, Bartek J, Gorgoulis VG. Evangelou K, et al. Among authors: trougakos ip. Cell Death Differ. 2013 Nov;20(11):1485-97. doi: 10.1038/cdd.2013.76. Epub 2013 Jul 12. Cell Death Differ. 2013. PMID: 23852374 Free PMC article.
195 results