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Novel antiplatelet role for a protein disulfide isomerase-targeted peptide: evidence of covalent binding to the C-terminal CGHC redox motif.
Sousa HR, Gaspar RS, Sena EM, da Silva SA, Fontelles JL, AraUjo TL, Mastrogiovanni M, Fries DM, Azevedo-Santos AP, Laurindo FR, Trostchansky A, Paes AM. Sousa HR, et al. Among authors: trostchansky a. J Thromb Haemost. 2017 Apr;15(4):774-784. doi: 10.1111/jth.13633. Epub 2017 Feb 28. J Thromb Haemost. 2017. PMID: 28109047 Free article.
Nitroarachidonic acid (NO2AA) inhibits protein disulfide isomerase (PDI) through reversible covalent adduct formation with critical cysteines.
González-Perilli L, Mastrogiovanni M, de Castro Fernandes D, Rubbo H, Laurindo F, Trostchansky A. González-Perilli L, et al. Among authors: trostchansky a. Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt A):1131-1139. doi: 10.1016/j.bbagen.2017.02.013. Epub 2017 Feb 12. Biochim Biophys Acta Gen Subj. 2017. PMID: 28215702
Nitroxide 4-hydroxy-2,2',6,6'-tetramethylpiperidine 1-oxyl (Tempol) inhibits the reductase activity of protein disulfide isomerase via covalent binding to the Cys400 residue on CXXC redox motif at the a'active site.
Santos GB, Gonzalez-Perilli L, Mastrogiovanni M, Aicardo A, Cerdeira CD, Trostchansky A, Brigagão MRPL. Santos GB, et al. Among authors: trostchansky a. Chem Biol Interact. 2017 Jun 25;272:117-124. doi: 10.1016/j.cbi.2017.05.015. Epub 2017 May 19. Chem Biol Interact. 2017. PMID: 28532685
Corrigendum to "Protective Effects of a Polyphenol-Rich Extract from Syzygium cumini (L.) Skeels Leaf on Oxidative Stress-Induced Diabetic Rats".
Chagas VT, de Sousa Coelho RMR, Gaspar RS, da Silva SA, Mastrogiovanni M, de Jesus Mendonça C, de Sousa Ribeiro MN, de Andrade Paes AM, Trostchansky A. Chagas VT, et al. Among authors: trostchansky a. Oxid Med Cell Longev. 2019 Jan 9;2019:5785798. doi: 10.1155/2019/5785798. eCollection 2019. Oxid Med Cell Longev. 2019. PMID: 30728887 Free PMC article.
Lipid Metabolism and Signaling in Platelet Function.
Paes AMA, Gaspar RS, Fuentes E, Wehinger S, Palomo I, Trostchansky A. Paes AMA, et al. Among authors: trostchansky a. Adv Exp Med Biol. 2019;1127:97-115. doi: 10.1007/978-3-030-11488-6_7. Adv Exp Med Biol. 2019. PMID: 31140174 Review.
72 results