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NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62.
Nat Commun. 2023 Dec 19;14(1):8368. doi: 10.1038/s41467-023-44033-0.
Nat Commun. 2023.
PMID: 38114471
Free PMC article.
The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system.
Saha I, Yuste-Checa P, Da Silva Padilha M, Guo Q, Körner R, Holthusen H, Trinkaus VA, Dudanova I, Fernández-Busnadiego R, Baumeister W, Sanders DW, Gautam S, Diamond MI, Hartl FU, Hipp MS.
Saha I, et al. Among authors: trinkaus va.
Nat Commun. 2023 Feb 2;14(1):560. doi: 10.1038/s41467-023-36058-2.
Nat Commun. 2023.
PMID: 36732333
Free PMC article.
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The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends.
Schneider MM, Gautam S, Herling TW, Andrzejewska E, Krainer G, Miller AM, Trinkaus VA, Peter QAE, Ruggeri FS, Vendruscolo M, Bracher A, Dobson CM, Hartl FU, Knowles TPJ.
Schneider MM, et al. Among authors: trinkaus va.
Nat Commun. 2021 Oct 14;12(1):5999. doi: 10.1038/s41467-021-25966-w.
Nat Commun. 2021.
PMID: 34650037
Free PMC article.
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The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model.
Yuste-Checa P, Trinkaus VA, Riera-Tur I, Imamoglu R, Schaller TF, Wang H, Dudanova I, Hipp MS, Bracher A, Hartl FU.
Yuste-Checa P, et al. Among authors: trinkaus va.
Nat Commun. 2021 Aug 11;12(1):4863. doi: 10.1038/s41467-021-25060-1.
Nat Commun. 2021.
PMID: 34381050
Free PMC article.
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In situ architecture of neuronal α-Synuclein inclusions.
Trinkaus VA, Riera-Tur I, Martínez-Sánchez A, Bäuerlein FJB, Guo Q, Arzberger T, Baumeister W, Dudanova I, Hipp MS, Hartl FU, Fernández-Busnadiego R.
Trinkaus VA, et al.
Nat Commun. 2021 Apr 14;12(1):2110. doi: 10.1038/s41467-021-22108-0.
Nat Commun. 2021.
PMID: 33854052
Free PMC article.
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