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Cross-talk between chronic lymphocytic leukemia (CLL) tumor B cells and mesenchymal stromal cells (MSCs): implications for neoplastic cell survival.
Trimarco V, Ave E, Facco M, Chiodin G, Frezzato F, Martini V, Gattazzo C, Lessi F, Giorgi CA, Visentin A, Castelli M, Severin F, Zambello R, Piazza F, Semenzato G, Trentin L. Trimarco V, et al. Oncotarget. 2015 Dec 8;6(39):42130-49. doi: 10.18632/oncotarget.6239. Oncotarget. 2015. PMID: 26517523 Free PMC article.
Cortactin, another player in the Lyn signaling pathway, is over-expressed and alternatively spliced in leukemic cells from patients with B-cell chronic lymphocytic leukemia.
Gattazzo C, Martini V, Frezzato F, Trimarco V, Tibaldi E, Castelli M, Facco M, Zonta F, Brunati AM, Zambello R, Semenzato G, Trentin L. Gattazzo C, et al. Among authors: trimarco v. Haematologica. 2014 Jun;99(6):1069-77. doi: 10.3324/haematol.2013.090183. Epub 2014 Feb 14. Haematologica. 2014. PMID: 24532043 Free PMC article.
Cortactin, a Lyn substrate, is a checkpoint molecule at the intersection of BCR and CXCR4 signalling pathway in chronic lymphocytic leukaemia cells.
Martini V, Gattazzo C, Frezzato F, Trimarco V, Pizzi M, Chiodin G, Severin F, Scomazzon E, Guzzardo V, Saraggi D, Raggi F, Martinello L, Facco M, Visentin A, Piazza F, Brunati AM, Semenzato G, Trentin L. Martini V, et al. Among authors: trimarco v. Br J Haematol. 2017 Jul;178(1):81-93. doi: 10.1111/bjh.14642. Epub 2017 Apr 17. Br J Haematol. 2017. PMID: 28419476 Free article.
Mitochondrial apoptosis is induced by Alkoxy phenyl-1-propanone derivatives through PP2A-mediated dephosphorylation of Bad and Foxo3A in CLL.
Pagano MA, Tibaldi E, Molino P, Frezzato F, Trimarco V, Facco M, Zagotto G, Ribaudo G, Leanza L, Peruzzo R, Szabò I, Visentin A, Frasson M, Semenzato G, Trentin L, Brunati AM. Pagano MA, et al. Among authors: trimarco v. Leukemia. 2019 May;33(5):1148-1160. doi: 10.1038/s41375-018-0288-5. Epub 2018 Oct 23. Leukemia. 2019. PMID: 30353029
In Chronic Lymphocytic Leukemia the JAK2/STAT3 Pathway Is Constitutively Activated and Its Inhibition Leads to CLL Cell Death Unaffected by the Protective Bone Marrow Microenvironment.
Severin F, Frezzato F, Visentin A, Martini V, Trimarco V, Carraro S, Tibaldi E, Brunati AM, Piazza F, Semenzato G, Facco M, Trentin L. Severin F, et al. Among authors: trimarco v. Cancers (Basel). 2019 Dec 4;11(12):1939. doi: 10.3390/cancers11121939. Cancers (Basel). 2019. PMID: 31817171 Free PMC article.
Treatment Induced Cytotoxic T-Cell Modulation in Multiple Myeloma Patients.
Barilà G, Pavan L, Vedovato S, Berno T, Lo Schirico M, Arangio Febbo M, Teramo A, Calabretto G, Vicenzetto C, Gasparini VR, Fregnani A, Manni S, Trimarco V, Carraro S, Facco M, Piazza F, Semenzato G, Zambello R. Barilà G, et al. Among authors: trimarco v. Front Oncol. 2021 Jun 15;11:682658. doi: 10.3389/fonc.2021.682658. eCollection 2021. Front Oncol. 2021. PMID: 34211851 Free PMC article.
Leukaemic cells from chronic lymphocytic leukaemia patients undergo apoptosis following microtubule depolymerization and Lyn inhibition by nocodazole.
Frezzato F, Trimarco V, Martini V, Gattazzo C, Ave E, Visentin A, Cabrelle A, Olivieri V, Zambello R, Facco M, Zonta F, Cristiani A, Brunati AM, Moro S, Semenzato G, Trentin L. Frezzato F, et al. Among authors: trimarco v. Br J Haematol. 2014 Jun;165(5):659-72. doi: 10.1111/bjh.12815. Epub 2014 Mar 7. Br J Haematol. 2014. PMID: 24606526 Free article.
Intrinsic and extrinsic mechanisms contribute to maintain the JAK/STAT pathway aberrantly activated in T-type large granular lymphocyte leukemia.
Teramo A, Gattazzo C, Passeri F, Lico A, Tasca G, Cabrelle A, Martini V, Frezzato F, Trimarco V, Ave E, Boscaro E, Piazza F, Facco M, Trentin L, Semenzato G, Zambello R. Teramo A, et al. Among authors: trimarco v. Blood. 2013 May 9;121(19):3843-54, S1. doi: 10.1182/blood-2012-07-441378. Epub 2013 Mar 20. Blood. 2013. PMID: 23515927 Free article.
132 results