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Canonical and atypical E2Fs regulate the mammalian endocycle.
Chen HZ, Ouseph MM, Li J, Pécot T, Chokshi V, Kent L, Bae S, Byrne M, Duran C, Comstock G, Trikha P, Mair M, Senapati S, Martin CK, Gandhi S, Wilson N, Liu B, Huang YW, Thompson JC, Raman S, Singh S, Leone M, Machiraju R, Huang K, Mo X, Fernandez S, Kalaszczynska I, Wolgemuth DJ, Sicinski P, Huang T, Jin V, Leone G. Chen HZ, et al. Among authors: trikha p. Nat Cell Biol. 2012 Nov;14(11):1192-202. doi: 10.1038/ncb2595. Epub 2012 Oct 14. Nat Cell Biol. 2012. PMID: 23064266 Free PMC article.
E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells.
Chong JL, Wenzel PL, Sáenz-Robles MT, Nair V, Ferrey A, Hagan JP, Gomez YM, Sharma N, Chen HZ, Ouseph M, Wang SH, Trikha P, Culp B, Mezache L, Winton DJ, Sansom OJ, Chen D, Bremner R, Cantalupo PG, Robinson ML, Pipas JM, Leone G. Chong JL, et al. Among authors: trikha p. Nature. 2009 Dec 17;462(7275):930-4. doi: 10.1038/nature08677. Nature. 2009. PMID: 20016602 Free PMC article.
Mouse development with a single E2F activator.
Tsai SY, Opavsky R, Sharma N, Wu L, Naidu S, Nolan E, Feria-Arias E, Timmers C, Opavska J, de Bruin A, Chong JL, Trikha P, Fernandez SA, Stromberg P, Rosol TJ, Leone G. Tsai SY, et al. Among authors: trikha p. Nature. 2008 Aug 28;454(7208):1137-41. doi: 10.1038/nature07066. Epub 2008 Jun 25. Nature. 2008. PMID: 18594513 Free PMC article.
E2f3 in tumor macrophages promotes lung metastasis.
Trikha P, Sharma N, Pena C, Reyes A, Pécot T, Khurshid S, Rawahneh M, Moffitt J, Stephens JA, Fernandez SA, Ostrowski MC, Leone G. Trikha P, et al. Oncogene. 2016 Jul 14;35(28):3636-46. doi: 10.1038/onc.2015.429. Epub 2015 Nov 9. Oncogene. 2016. PMID: 26549026 Free PMC article.
E2f1-3 are critical for myeloid development.
Trikha P, Sharma N, Opavsky R, Reyes A, Pena C, Ostrowski MC, Roussel MF, Leone G. Trikha P, et al. J Biol Chem. 2011 Feb 11;286(6):4783-95. doi: 10.1074/jbc.M110.182733. Epub 2010 Nov 28. J Biol Chem. 2011. PMID: 21115501 Free PMC article.
CpG island methylation in a mouse model of lymphoma is driven by the genetic configuration of tumor cells.
Opavsky R, Wang SH, Trikha P, Raval A, Huang Y, Wu YZ, Rodriguez B, Keller B, Liyanarachchi S, Wei G, Davuluri RV, Weinstein M, Felsher D, Ostrowski M, Leone G, Plass C. Opavsky R, et al. Among authors: trikha p. PLoS Genet. 2007 Sep;3(9):1757-69. doi: 10.1371/journal.pgen.0030167. Epub 2007 Aug 16. PLoS Genet. 2007. PMID: 17907813 Free PMC article.
S100A7 enhances mammary tumorigenesis through upregulation of inflammatory pathways.
Nasser MW, Qamri Z, Deol YS, Ravi J, Powell CA, Trikha P, Schwendener RA, Bai XF, Shilo K, Zou X, Leone G, Wolf R, Yuspa SH, Ganju RK. Nasser MW, et al. Among authors: trikha p. Cancer Res. 2012 Feb 1;72(3):604-15. doi: 10.1158/0008-5472.CAN-11-0669. Epub 2011 Dec 12. Cancer Res. 2012. PMID: 22158945 Free PMC article.
41 results