Treston AM - Search Results

1

Structure-Based Design of Potent Iminosugar Inhibitors of Endoplasmic Reticulum α-Glucosidase I with Anti-SARS-CoV-2 Activity.

Karade SS, Franco EJ, Rojas AC, Hanrahan KC, Kolesnikov A, Yu W, MacKerell AD Jr, Hill DC, Weber DJ, Brown AN, Treston AM, Mariuzza RA. Karade SS, et al. Among authors: treston am. J Med Chem. 2023 Feb 23;66(4):2744-2760. doi: 10.1021/acs.jmedchem.2c01750. Epub 2023 Feb 10. J Med Chem. 2023. PMID: 36762932 Free PMC article.

2

N-Substituted Valiolamine Derivatives as Potent Inhibitors of Endoplasmic Reticulum α-Glucosidases I and II with Antiviral Activity.

Karade SS, Hill ML, Kiappes JL, Manne R, Aakula B, Zitzmann N, Warfield KL, Treston AM, Mariuzza RA. Karade SS, et al. Among authors: treston am. J Med Chem. 2021 Dec 23;64(24):18010-18024. doi: 10.1021/acs.jmedchem.1c01377. Epub 2021 Dec 6. J Med Chem. 2021. PMID: 34870992

3

Identification of Endoplasmic Reticulum α-Glucosidase I from a Thermophilic Fungus as a Platform for Structure-Guided Antiviral Drug Design.

Karade SS, Kolesnikov A, Treston AM, Mariuzza RA. Karade SS, et al. Among authors: treston am. Biochemistry. 2022 May 17;61(10):822-832. doi: 10.1021/acs.biochem.2c00092. Epub 2022 Apr 27. Biochemistry. 2022. PMID: 35476408

4

Targeting Endoplasmic Reticulum α-Glucosidase I with a Single-Dose Iminosugar Treatment Protects against Lethal Influenza and Dengue Virus Infections.

Warfield KL, Alonzi DS, Hill JC, Caputo AT, Roversi P, Kiappes JL, Sheets N, Duchars M, Dwek RA, Biggins J, Barnard D, Shresta S, Treston AM, Zitzmann N. Warfield KL, et al. Among authors: treston am. J Med Chem. 2020 Apr 23;63(8):4205-4214. doi: 10.1021/acs.jmedchem.0c00067. Epub 2020 Apr 15. J Med Chem. 2020. PMID: 32227946

5

Synthesis and enantiomeric separation of 2-phthalimidino-glutaric acid analogues: potent inhibitors of tumor metastasis.

Shah JH, Swartz GM, Papathanassiu AE, Treston AM, Fogler WE, Madsen JW, Green SJ. Shah JH, et al. Among authors: treston am. J Med Chem. 1999 Aug 12;42(16):3014-7. doi: 10.1021/jm990083y. J Med Chem. 1999. PMID: 10447943 No abstract available.

6

Randomized single oral dose phase 1 study of safety, tolerability, and pharmacokinetics of Iminosugar UV-4 Hydrochloride (UV-4B) in healthy subjects.

Callahan M, Treston AM, Lin G, Smith M, Kaufman B, Khaliq M, Evans DeWald L, Spurgers K, Warfield KL, Lowe P, Duchars M, Sampath A, Ramstedt U. Callahan M, et al. Among authors: treston am. PLoS Negl Trop Dis. 2022 Aug 8;16(8):e0010636. doi: 10.1371/journal.pntd.0010636. eCollection 2022 Aug. PLoS Negl Trop Dis. 2022. PMID: 35939501 Free PMC article. Clinical Trial.

7

Synthesis and in vivo antitumor evaluation of 2-methoxyestradiol 3-phosphate, 17-phosphate, and 3,17-diphosphate.

Edsall AB, Agoston GE, Treston AM, Plum SM, McClanahan RH, Lu TS, Song W, Cushman M. Edsall AB, et al. Among authors: treston am. J Med Chem. 2007 Dec 27;50(26):6700-5. doi: 10.1021/jm070639e. Epub 2007 Dec 6. J Med Chem. 2007. PMID: 18052315

8

Synthesis of 2- and 17-substituted estrone analogs and their antiproliferative structure-activity relationships compared to 2-methoxyestradiol.

Shah JH, Agoston GE, Suwandi L, Hunsucker K, Pribluda V, Zhan XH, Swartz GM, LaVallee TM, Treston AM. Shah JH, et al. Among authors: treston am. Bioorg Med Chem. 2009 Oct 15;17(20):7344-52. doi: 10.1016/j.bmc.2009.08.038. Epub 2009 Aug 21. Bioorg Med Chem. 2009. PMID: 19762246

9

Synthesis and structure-activity relationships of 16-modified analogs of 2-methoxyestradiol.

Agoston GE, Shah JH, Lavallee TM, Zhan X, Pribluda VS, Treston AM. Agoston GE, et al. Among authors: treston am. Bioorg Med Chem. 2007 Dec 15;15(24):7524-37. doi: 10.1016/j.bmc.2007.09.011. Epub 2007 Sep 14. Bioorg Med Chem. 2007. PMID: 17910916

10

Reproductive and developmental toxicology studies of iminosugar UV-4.

Shearer J, Wolfe G, Khaliq M, Kaufman B, Sampath A, Warfield KL, Ramstedt U, Treston A. Shearer J, et al. Reprod Toxicol. 2022 Dec;114:9-21. doi: 10.1016/j.reprotox.2022.09.007. Epub 2022 Oct 4. Reprod Toxicol. 2022. PMID: 36206921 Free article.

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