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Discovery of novel oxazole-based macrocycles as anti-coronaviral agents targeting SARS-CoV-2 main protease.
Al-Wahaibi LH, Mostafa A, Mostafa YA, Abou-Ghadir OF, Abdelazeem AH, Gouda AM, Kutkat O, Abo Shama NM, Shehata M, Gomaa HAM, Abdelrahman MH, Mohamed FAM, Gu X, Ali MA, Trembleau L, Youssif BGM. Al-Wahaibi LH, et al. Among authors: trembleau l. Bioorg Chem. 2021 Nov;116:105363. doi: 10.1016/j.bioorg.2021.105363. Epub 2021 Sep 17. Bioorg Chem. 2021. PMID: 34555629 Free PMC article.
Design, synthesis, and biological evaluation of novel EGFR inhibitors containing 5-chloro-3-hydroxymethyl-indole-2-carboxamide scaffold with apoptotic antiproliferative activity.
Mohamed FAM, Gomaa HAM, Hendawy OM, Ali AT, Farghaly HS, Gouda AM, Abdelazeem AH, Abdelrahman MH, Trembleau L, Youssif BGM. Mohamed FAM, et al. Among authors: trembleau l. Bioorg Chem. 2021 Jul;112:104960. doi: 10.1016/j.bioorg.2021.104960. Epub 2021 May 1. Bioorg Chem. 2021. PMID: 34020242
Optimization and SAR investigation of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as EGFR and BRAFV600E dual inhibitors with potent antiproliferative and antioxidant activities.
Gomaa HAM, Shaker ME, Alzarea SI, Hendawy OM, Mohamed FAM, Gouda AM, Ali AT, Morcoss MM, Abdelrahman MH, Trembleau L, Youssif BGM. Gomaa HAM, et al. Among authors: trembleau l. Bioorg Chem. 2022 Mar;120:105616. doi: 10.1016/j.bioorg.2022.105616. Epub 2022 Jan 19. Bioorg Chem. 2022. PMID: 35078049
Discovery of new 5-substituted-indole-2-carboxamides as dual epidermal growth factor receptor (EGFR)/cyclin dependent kinase-2 (CDK2) inhibitors with potent antiproliferative action.
Mohamed FAM, Alakilli SYM, El Azab EF, Baawad FAM, Shaaban EIA, Alrub HA, Hendawy O, Gomaa HAM, Bakr AG, Abdelrahman MH, Trembleau L, Mohammed AF, Youssif BGM. Mohamed FAM, et al. Among authors: trembleau l. RSC Med Chem. 2023 Mar 16;14(4):734-744. doi: 10.1039/d3md00038a. eCollection 2023 Apr 26. RSC Med Chem. 2023. PMID: 37122549 Free PMC article.
50 results