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Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis.
Sveidahl Johansen O, Ma T, Hansen JB, Markussen LK, Schreiber R, Reverte-Salisa L, Dong H, Christensen DP, Sun W, Gnad T, Karavaeva I, Nielsen TS, Kooijman S, Cero C, Dmytriyeva O, Shen Y, Razzoli M, O'Brien SL, Kuipers EN, Nielsen CH, Orchard W, Willemsen N, Jespersen NZ, Lundh M, Sustarsic EG, Hallgren CM, Frost M, McGonigle S, Isidor MS, Broholm C, Pedersen O, Hansen JB, Grarup N, Hansen T, Kjær A, Granneman JG, Babu MM, Calebiro D, Nielsen S, Rydén M, Soccio R, Rensen PCN, Treebak JT, Schwartz TW, Emanuelli B, Bartolomucci A, Pfeifer A, Zechner R, Scheele C, Mandrup S, Gerhart-Hines Z. Sveidahl Johansen O, et al. Among authors: treebak jt. Cell. 2021 Jun 24;184(13):3502-3518.e33. doi: 10.1016/j.cell.2021.04.037. Epub 2021 May 27. Cell. 2021. PMID: 34048700 Free PMC article.
A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes.
Moltke I, Grarup N, Jørgensen ME, Bjerregaard P, Treebak JT, Fumagalli M, Korneliussen TS, Andersen MA, Nielsen TS, Krarup NT, Gjesing AP, Zierath JR, Linneberg A, Wu X, Sun G, Jin X, Al-Aama J, Wang J, Borch-Johnsen K, Pedersen O, Nielsen R, Albrechtsen A, Hansen T. Moltke I, et al. Among authors: treebak jt. Nature. 2014 Aug 14;512(7513):190-3. doi: 10.1038/nature13425. Epub 2014 Jun 18. Nature. 2014. PMID: 25043022
Dietary fat drives whole-body insulin resistance and promotes intestinal inflammation independent of body weight gain.
Jensen BA, Nielsen TS, Fritzen AM, Holm JB, Fjære E, Serup AK, Borkowski K, Risis S, Pærregaard SI, Søgaard I, Poupeau A, Poulsen M, Ma T, Sina C, Kiens B, Madsen L, Kristiansen K, Treebak JT. Jensen BA, et al. Among authors: treebak jt. Metabolism. 2016 Dec;65(12):1706-1719. doi: 10.1016/j.metabol.2016.09.002. Epub 2016 Sep 12. Metabolism. 2016. PMID: 27832859 Free article.
The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones.
Rudenko O, Shang J, Munk A, Ekberg JP, Petersen N, Engelstoft MS, Egerod KL, Hjorth SA, Wu M, Feng Y, Zhou YP, Mokrosinski J, Thams P, Reimann F, Gribble F, Rehfeld JF, Holst JJ, Treebak JT, Howard AD, Schwartz TW. Rudenko O, et al. Among authors: treebak jt. Mol Metab. 2019 Jan;19:49-64. doi: 10.1016/j.molmet.2018.10.012. Epub 2018 Nov 5. Mol Metab. 2019. PMID: 30472415 Free PMC article.
ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations.
Graae AS, Grarup N, Ribel-Madsen R, Lystbæk SH, Boesgaard T, Staiger H, Fritsche A, Wellner N, Sulek K, Kjolby M, Backe MB, Chubanava S, Prats C, Serup AK, Birk JB, Dubail J, Gillberg L, Vienberg SG, Nykjær A, Kiens B, Wojtaszewski JFP, Larsen S, Apte SS, Häring HU, Vaag A, Zethelius B, Pedersen O, Treebak JT, Hansen T, Holst B. Graae AS, et al. Among authors: treebak jt. Diabetes. 2019 Mar;68(3):502-514. doi: 10.2337/db18-0418. Epub 2019 Jan 9. Diabetes. 2019. PMID: 30626608 Free PMC article.
112 results