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Discovery and Derivatization of Tridecaptin Antibiotics with Altered Host Specificity and Enhanced Bioactivity.
Machushynets NV, Al Ayed K, Terlouw BR, Du C, Buijs NP, Willemse J, Elsayed SS, Schill J, Trebosc V, Pieren M, Alexander FM, Cochrane SA, Liles MR, Medema MH, Martin NI, van Wezel GP. Machushynets NV, et al. Among authors: trebosc v. ACS Chem Biol. 2024 Apr 11. doi: 10.1021/acschembio.4c00034. Online ahead of print. ACS Chem Biol. 2024. PMID: 38602492
Total Synthesis and Structure Assignment of the Relacidine Lipopeptide Antibiotics and Preparation of Analogues with Enhanced Stability.
Al Ayed K, Zamarbide Losada D, Machushynets NV, Terlouw B, Elsayed SS, Schill J, Trebosc V, Pieren M, Medema MH, van Wezel GP, Martin NI. Al Ayed K, et al. Among authors: trebosc v. ACS Infect Dis. 2023 Apr 14;9(4):739-748. doi: 10.1021/acsinfecdis.3c00043. Epub 2023 Mar 31. ACS Infect Dis. 2023. PMID: 37000899 Free PMC article.
Structure-activity relationships of actively FhuE transported rifabutin derivatives with potent activity against Acinetobacter baumannii.
Maingot M, Bourotte M, Vetter AC, Schellhorn B, Antraygues K, Scherer H, Gitzinger M, Kemmer C, Dale GE, Defert O, Lociuro S, Brönstrup M, Willand N, Trebosc V. Maingot M, et al. Among authors: trebosc v. Eur J Med Chem. 2023 Apr 5;252:115257. doi: 10.1016/j.ejmech.2023.115257. Epub 2023 Mar 16. Eur J Med Chem. 2023. PMID: 36948128
Targeting virulence regulation to disarm Acinetobacter baumannii pathogenesis.
Trebosc V, Lucchini V, Narwal M, Wicki B, Gartenmann S, Schellhorn B, Schill J, Bourotte M, Frey D, Grünberg J, Trauner A, Ferrari L, Felici A, Champion OL, Gitzinger M, Lociuro S, Kammerer RA, Kemmer C, Pieren M. Trebosc V, et al. Virulence. 2022 Dec;13(1):1868-1883. doi: 10.1080/21505594.2022.2135273. Virulence. 2022. PMID: 36261919 Free PMC article.
In vitro activity of rifabutin against 293 contemporary carbapenem-resistant Acinetobacter baumannii clinical isolates and characterization of rifabutin mode of action and resistance mechanisms.
Trebosc V, Schellhorn B, Schill J, Lucchini V, Bühler J, Bourotte M, Butcher JJ, Gitzinger M, Lociuro S, Kemmer C, Dale GE. Trebosc V, et al. J Antimicrob Chemother. 2020 Dec 1;75(12):3552-3562. doi: 10.1093/jac/dkaa370. J Antimicrob Chemother. 2020. PMID: 32869081 Free PMC article.
A nutrient-limited screen unmasks rifabutin hyperactivity for extensively drug-resistant Acinetobacter baumannii.
Luna B, Trebosc V, Lee B, Bakowski M, Ulhaq A, Yan J, Lu P, Cheng J, Nielsen T, Lim J, Ketphan W, Eoh H, McNamara C, Skandalis N, She R, Kemmer C, Lociuro S, Dale GE, Spellberg B. Luna B, et al. Among authors: trebosc v. Nat Microbiol. 2020 Sep;5(9):1134-1143. doi: 10.1038/s41564-020-0737-6. Epub 2020 Jun 8. Nat Microbiol. 2020. PMID: 32514072 Free PMC article.
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