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The Ig VH complementarity-determining region 3-containing Rb9 peptide, inhibits melanoma cells migration and invasion by interactions with Hsp90 and an adhesion G-protein coupled receptor.
Girola N, Matsuo AL, Figueiredo CR, Massaoka MH, Farias CF, Arruda DC, Azevedo RA, Monteiro HP, Resende-Lara PT, Cunha RL, Polonelli L, Travassos LR. Girola N, et al. Among authors: travassos lr. Peptides. 2016 Nov;85:1-15. doi: 10.1016/j.peptides.2016.08.006. Epub 2016 Aug 26. Peptides. 2016. PMID: 27575453
Jacaranone induces apoptosis in melanoma cells via ROS-mediated downregulation of Akt and p38 MAPK activation and displays antitumor activity in vivo.
Massaoka MH, Matsuo AL, Figueiredo CR, Farias CF, Girola N, Arruda DC, Scutti JA, Romoff P, Favero OA, Ferreira MJ, Lago JH, Travassos LR. Massaoka MH, et al. Among authors: travassos lr. PLoS One. 2012;7(6):e38698. doi: 10.1371/journal.pone.0038698. Epub 2012 Jun 6. PLoS One. 2012. PMID: 22701695 Free PMC article.
Requirement of mitogen-activated protein kinases and I kappa B phosphorylation for induction of proinflammatory cytokines synthesis by macrophages indicates functional similarity of receptors triggered by glycosylphosphatidylinositol anchors from parasitic protozoa and bacterial lipopolysaccharide.
Ropert C, Almeida IC, Closel M, Travassos LR, Ferguson MA, Cohen P, Gazzinelli RT. Ropert C, et al. Among authors: travassos lr. J Immunol. 2001 Mar 1;166(5):3423-31. doi: 10.4049/jimmunol.166.5.3423. J Immunol. 2001. PMID: 11207300
243 results