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FGF21, a liver hormone that inhibits alcohol intake in mice, increases in human circulation after acute alcohol ingestion and sustained binge drinking at Oktoberfest.
Søberg S, Andersen ES, Dalsgaard NB, Jarlhelt I, Hansen NL, Hoffmann N, Vilsbøll T, Chenchar A, Jensen M, Grevengoed TJ, Trammell SAJ, Knop FK, Gillum MP. Søberg S, et al. Among authors: trammell saj. Mol Metab. 2018 May;11:96-103. doi: 10.1016/j.molmet.2018.03.010. Epub 2018 Mar 27. Mol Metab. 2018. PMID: 29627377 Free PMC article.
N-acyl taurines are endogenous lipid messengers that improve glucose homeostasis.
Grevengoed TJ, Trammell SAJ, McKinney MK, Petersen N, Cardone RL, Svenningsen JS, Ogasawara D, Nexøe-Larsen CC, Knop FK, Schwartz TW, Kibbey RG, Cravatt BF, Gillum MP. Grevengoed TJ, et al. Among authors: trammell saj. Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24770-24778. doi: 10.1073/pnas.1916288116. Epub 2019 Nov 18. Proc Natl Acad Sci U S A. 2019. PMID: 31740614 Free PMC article.
Fasting- and ghrelin-induced food intake is regulated by NAMPT in the hypothalamus.
de Guia RM, Hassing AS, Skov LJ, Ratner C, Plucińska K, Madsen S, Diep TA, Dela Cruz GV, Trammell SAJ, Sustarsic EG, Emanuelli B, Gillum MP, Gerhart-Hines Z, Holst B, Treebak JT. de Guia RM, et al. Among authors: trammell saj. Acta Physiol (Oxf). 2020 Apr;228(4):e13437. doi: 10.1111/apha.13437. Epub 2020 Jan 14. Acta Physiol (Oxf). 2020. PMID: 31900990
Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis.
Winther-Sørensen M, Galsgaard KD, Santos A, Trammell SAJ, Sulek K, Kuhre RE, Pedersen J, Andersen DB, Hassing AS, Dall M, Treebak JT, Gillum MP, Torekov SS, Windeløv JA, Hunt JE, Kjeldsen SAS, Jepsen SL, Vasilopoulou CG, Knop FK, Ørskov C, Werge MP, Bisgaard HC, Eriksen PL, Vilstrup H, Gluud LL, Holst JJ, Wewer Albrechtsen NJ. Winther-Sørensen M, et al. Among authors: trammell saj. Mol Metab. 2020 Dec;42:101080. doi: 10.1016/j.molmet.2020.101080. Epub 2020 Sep 13. Mol Metab. 2020. PMID: 32937194 Free PMC article.
FGF21 suppresses alcohol consumption through an amygdalo-striatal circuit.
Flippo KH, Trammell SAJ, Gillum MP, Aklan I, Perez MB, Yavuz Y, Smith NK, Jensen-Cody SO, Zhou B, Claflin KE, Beierschmitt A, Fink-Jensen A, Knop FK, Palmour RM, Grueter BA, Atasoy D, Potthoff MJ. Flippo KH, et al. Among authors: trammell saj. Cell Metab. 2022 Feb 1;34(2):317-328.e6. doi: 10.1016/j.cmet.2021.12.024. Cell Metab. 2022. PMID: 35108517 Free PMC article.
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