Toyooka N - Search Results

1

Discovery and Structure-Based Optimization of Novel Atg4B Inhibitors for the Treatment of Castration-Resistant Prostate Cancer.

Kudo Y, Endo S, Fujita M, Ota A, Kamatari YO, Tanaka Y, Ishikawa T, Ikeda H, Okada T, Toyooka N, Fujimoto N, Matsunaga T, Ikari A. Kudo Y, et al. Among authors: toyooka n. J Med Chem. 2022 Mar 24;65(6):4878-4892. doi: 10.1021/acs.jmedchem.1c02113. Epub 2022 Mar 4. J Med Chem. 2022. PMID: 35244402

2

Design, synthesis, and biological evaluation of novel (1-thioxo-1,2,3,4-tetrahydro-β-carbolin-9-yl)acetic acids as selective inhibitors for AKR1B1.

Minehira D, Takeda D, Urata H, Kato A, Adachi I, Wang X, Matsuya Y, Sugimoto K, Takemura M, Endo S, Matsunaga T, Hara A, Koseki J, Narukawa K, Hirono S, Toyooka N. Minehira D, et al. Among authors: toyooka n. Bioorg Med Chem. 2012 Jan 1;20(1):356-67. doi: 10.1016/j.bmc.2011.10.073. Epub 2011 Nov 3. Bioorg Med Chem. 2012. PMID: 22104435

3

Design, synthesis and evaluation of caffeic acid phenethyl ester-based inhibitors targeting a selectivity pocket in the active site of human aldo-keto reductase 1B10.

Soda M, Hu D, Endo S, Takemura M, Li J, Wada R, Ifuku S, Zhao HT, El-Kabbani O, Ohta S, Yamamura K, Toyooka N, Hara A, Matsunaga T. Soda M, et al. Among authors: toyooka n. Eur J Med Chem. 2012 Feb;48:321-9. doi: 10.1016/j.ejmech.2011.12.034. Epub 2011 Dec 29. Eur J Med Chem. 2012. PMID: 22236472

4

Selective inhibition of human type-5 17β-hydroxysteroid dehydrogenase (AKR1C3) by baccharin, a component of Brazilian propolis.

Endo S, Matsunaga T, Kanamori A, Otsuji Y, Nagai H, Sundaram K, El-Kabbani O, Toyooka N, Ohta S, Hara A. Endo S, et al. Among authors: toyooka n. J Nat Prod. 2012 Apr 27;75(4):716-21. doi: 10.1021/np201002x. Epub 2012 Apr 16. J Nat Prod. 2012. PMID: 22506594

5

Characterization of rabbit aldose reductase-like protein with 3β-hydroxysteroid dehydrogenase activity.

Endo S, Matsunaga T, Kumada S, Fujimoto A, Ohno S, El-Kabbani O, Hu D, Toyooka N, Mano J, Tajima K, Hara A. Endo S, et al. Among authors: toyooka n. Arch Biochem Biophys. 2012 Nov 1;527(1):23-30. doi: 10.1016/j.abb.2012.07.012. Epub 2012 Aug 1. Arch Biochem Biophys. 2012. PMID: 22874434

6

Synthesis and antitumor evaluation of arctigenin derivatives based on antiausterity strategy.

Kudou N, Taniguchi A, Sugimoto K, Matsuya Y, Kawasaki M, Toyooka N, Miyoshi C, Awale S, Dibwe DF, Esumi H, Kadota S, Tezuka Y. Kudou N, et al. Among authors: toyooka n. Eur J Med Chem. 2013 Feb;60:76-88. doi: 10.1016/j.ejmech.2012.11.031. Epub 2012 Nov 28. Eur J Med Chem. 2013. PMID: 23287053

7

Rational design and synthesis of 4-substituted 2-pyridin-2-ylamides with inhibitory effects on SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2).

Ichihara Y, Fujimura R, Tsuneki H, Wada T, Okamoto K, Gouda H, Hirono S, Sugimoto K, Matsuya Y, Sasaoka T, Toyooka N. Ichihara Y, et al. Among authors: toyooka n. Eur J Med Chem. 2013 Apr;62:649-60. doi: 10.1016/j.ejmech.2013.01.014. Epub 2013 Jan 28. Eur J Med Chem. 2013. PMID: 23434638

8

Structure-activity-relationship studies on dihydrofuran-fused perhydrophenanthrenes as an anti-Alzheimer's disease agent.

Sugimoto K, Tamura K, Tohda C, Toyooka N, Nemoto H, Matsuya Y. Sugimoto K, et al. Among authors: toyooka n. Bioorg Med Chem. 2013 Aug 1;21(15):4459-71. doi: 10.1016/j.bmc.2013.05.059. Epub 2013 Jun 5. Bioorg Med Chem. 2013. PMID: 23806833

9

Synthesis and structure-activity relationship of 2-phenyliminochromene derivatives as inhibitors for aldo-keto reductase (AKR) 1B10.

Endo S, Hu D, Suyama M, Matsunaga T, Sugimoto K, Matsuya Y, El-Kabbani O, Kuwata K, Hara A, Kitade Y, Toyooka N. Endo S, et al. Among authors: toyooka n. Bioorg Med Chem. 2013 Nov 1;21(21):6378-84. doi: 10.1016/j.bmc.2013.08.059. Epub 2013 Sep 6. Bioorg Med Chem. 2013. PMID: 24071447

10

In silico and pharmacological screenings identify novel serine racemase inhibitors.

Mori H, Wada R, Li J, Ishimoto T, Mizuguchi M, Obita T, Gouda H, Hirono S, Toyooka N. Mori H, et al. Among authors: toyooka n. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3732-5. doi: 10.1016/j.bmcl.2014.07.003. Epub 2014 Jul 5. Bioorg Med Chem Lett. 2014. PMID: 25066953

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