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Macrophage AMPK β1 activation by PF-06409577 reduces the inflammatory response, cholesterol synthesis, and atherosclerosis in mice.
Day EA, Townsend LK, Rehal S, Batchuluun B, Wang D, Morrow MR, Lu R, Lundenberg L, Lu JH, Desjardins EM, Smith TKT, Raphenya AR, McArthur AG, Fullerton MD, Steinberg GR. Day EA, et al. Among authors: townsend lk. iScience. 2023 Oct 20;26(11):108269. doi: 10.1016/j.isci.2023.108269. eCollection 2023 Nov 17. iScience. 2023. PMID: 38026185 Free PMC article.
Combination of an ACLY inhibitor with a GLP-1R agonist exerts additive benefits on nonalcoholic steatohepatitis and hepatic fibrosis in mice.
Desjardins EM, Wu J, Lavoie DCT, Ahmadi E, Townsend LK, Morrow MR, Wang D, Tsakiridis EE, Batchuluun B, Fayyazi R, Kwiecien JM, Tsakiridis T, Lally JSV, Paré G, Pinkosky SL, Steinberg GR. Desjardins EM, et al. Among authors: townsend lk. Cell Rep Med. 2023 Sep 19;4(9):101193. doi: 10.1016/j.xcrm.2023.101193. Cell Rep Med. 2023. PMID: 37729871 Free PMC article.
GDF15 promotes weight loss by enhancing energy expenditure in muscle.
Wang D, Townsend LK, DesOrmeaux GJ, Frangos SM, Batchuluun B, Dumont L, Kuhre RE, Ahmadi E, Hu S, Rebalka IA, Gautam J, Jabile MJT, Pileggi CA, Rehal S, Desjardins EM, Tsakiridis EE, Lally JSV, Juracic ES, Tupling AR, Gerstein HC, Paré G, Tsakiridis T, Harper ME, Hawke TJ, Speakman JR, Blondin DP, Holloway GP, Jørgensen SB, Steinberg GR. Wang D, et al. Among authors: townsend lk. Nature. 2023 Jul;619(7968):143-150. doi: 10.1038/s41586-023-06249-4. Epub 2023 Jun 28. Nature. 2023. PMID: 37380764 Free PMC article.
AMPK and the Endocrine Control of Metabolism.
Townsend LK, Steinberg GR. Townsend LK, et al. Endocr Rev. 2023 Sep 15;44(5):910-933. doi: 10.1210/endrev/bnad012. Endocr Rev. 2023. PMID: 37115289 Review.
GDF15 is an exercise-induced hepatokine regulated by glucagon and insulin in humans.
Plomgaard P, Hansen JS, Townsend LK, Gudiksen A, Secher NH, Clemmesen JO, Støving RK, Goetze JP, Wright DC, Pilegaard H. Plomgaard P, et al. Among authors: townsend lk. Front Endocrinol (Lausanne). 2022 Dec 5;13:1037948. doi: 10.3389/fendo.2022.1037948. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36545337 Free PMC article.
The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids.
Desjardins EM, Smith BK, Day EA, Ducommun S, Sanders MJ, Nederveen JP, Ford RJ, Pinkosky SL, Townsend LK, Gutgesell RM, Lu R, Sakamoto K, Steinberg GR. Desjardins EM, et al. Among authors: townsend lk. Proc Natl Acad Sci U S A. 2022 Nov 29;119(48):e2119824119. doi: 10.1073/pnas.2119824119. Epub 2022 Nov 21. Proc Natl Acad Sci U S A. 2022. PMID: 36409897 Free PMC article.
48 results