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Understanding and Improving the Membrane Permeability of VH032-Based PROTACs.
Klein VG, Townsend CE, Testa A, Zengerle M, Maniaci C, Hughes SJ, Chan KH, Ciulli A, Lokey RS. Klein VG, et al. Among authors: townsend ce. ACS Med Chem Lett. 2020 Jul 30;11(9):1732-1738. doi: 10.1021/acsmedchemlett.0c00265. eCollection 2020 Sep 10. ACS Med Chem Lett. 2020. PMID: 32939229 Free PMC article.
Lipophilic Permeability Efficiency Reconciles the Opposing Roles of Lipophilicity in Membrane Permeability and Aqueous Solubility.
Naylor MR, Ly AM, Handford MJ, Ramos DP, Pye CR, Furukawa A, Klein VG, Noland RP, Edmondson Q, Turmon AC, Hewitt WM, Schwochert J, Townsend CE, Kelly CN, Blanco MJ, Lokey RS. Naylor MR, et al. Among authors: townsend ce. J Med Chem. 2018 Dec 27;61(24):11169-11182. doi: 10.1021/acs.jmedchem.8b01259. Epub 2018 Dec 11. J Med Chem. 2018. PMID: 30395703
Conformation and Permeability: Cyclic Hexapeptide Diastereomers.
Ono S, Naylor MR, Townsend CE, Okumura C, Okada O, Lokey RS. Ono S, et al. Among authors: townsend ce. J Chem Inf Model. 2019 Jun 24;59(6):2952-2963. doi: 10.1021/acs.jcim.9b00217. Epub 2019 May 8. J Chem Inf Model. 2019. PMID: 31042375 Free PMC article.
Cyclosporin A: Conformational Complexity and Chameleonicity.
Ono S, Naylor MR, Townsend CE, Okumura C, Okada O, Lee HW, Lokey RS. Ono S, et al. Among authors: townsend ce. J Chem Inf Model. 2021 Nov 22;61(11):5601-5613. doi: 10.1021/acs.jcim.1c00771. Epub 2021 Oct 21. J Chem Inf Model. 2021. PMID: 34672629 Free PMC article.
36 results