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Novel furano analogues of duocarmycin C1 and C2: design, synthesis, and biological evaluation of seco-iso-cyclopropylfurano[2,3-e]indoline (seco-iso-CFI) and seco-cyclopropyltetrahydrofurano[2,3-f]quinoline (seco-CFQ) analogues.
Bioorg Med Chem. 2002 Sep;10(9):2941-52. doi: 10.1016/s0968-0896(02)00157-8.
Bioorg Med Chem. 2002.
PMID: 12110316
A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties.
Kupchinsky S, Centioni S, Howard T, Trzupek J, Roller S, Carnahan V, Townes H, Purnell B, Price C, Handl H, Summerville K, Johnson K, Toth J, Hudson S, Kiakos K, Hartley JA, Lee M.
Kupchinsky S, et al.
Bioorg Med Chem. 2004 Dec 1;12(23):6221-36. doi: 10.1016/j.bmc.2004.08.051.
Bioorg Med Chem. 2004.
PMID: 15519165
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Novel (S)-(-)- and R-(+)-seco-iso-cyclopropylfurano[e]indoline-5,6,7-trimethoxyindole-2-carboxamide (iso-CFI) analogs of duocarmycin C2: synthesis and biological evaluation.
Purnell B, Lingerfelt B, Scott A, Townes H, Summerville K, Hudson S, Kiakos K, Hartley JA, Lee M.
Purnell B, et al.
Med Chem. 2006 Mar;2(2):139-46. doi: 10.2174/157340606776056188.
Med Chem. 2006.
PMID: 16787363
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Unexpected syntheses of seco-cyclopropyltetrahydroquinolines - from a radical 5-exo-trig cyclization reaction: analogs of CC-1065 and the duocarmycins.
Pati H, Howard T, Townes H, Lingerfelt B, McNulty L, Lee M.
Pati H, et al.
Molecules. 2004 Feb 28;9(3):125-33. doi: 10.3390/90300125.
Molecules. 2004.
PMID: 18007417
Free PMC article.
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