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Clinical outcomes of a large cohort of individuals with the F508del/5T;TG12 CFTR genotype.
Tosco A, Castaldo A, Colombo C, Claut L, Carnovale V, Iacotucci P, Lucarelli M, Cimino G, Fabrizzi B, Caporelli N, Majo F, Ciciriello F, Padoan R, Poli P, Taccetti G, Centrone C, Casciaro R, Castellani C, Salvatore D, Colangelo C, Bonomi P, Castaldo G, Terlizzi V. Tosco A, et al. J Cyst Fibros. 2022 Sep;21(5):850-855. doi: 10.1016/j.jcf.2022.04.020. Epub 2022 May 4. J Cyst Fibros. 2022. PMID: 35523714
Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation.
De Stefano D, Villella VR, Esposito S, Tosco A, Sepe A, De Gregorio F, Salvadori L, Grassia R, Leone CA, De Rosa G, Maiuri MC, Pettoello-Mantovani M, Guido S, Bossi A, Zolin A, Venerando A, Pinna LA, Mehta A, Bona G, Kroemer G, Maiuri L, Raia V. De Stefano D, et al. Among authors: tosco a. Autophagy. 2014;10(11):2053-74. doi: 10.4161/15548627.2014.973737. Autophagy. 2014. PMID: 25350163 Free PMC article. Clinical Trial.
Randomized, single blind, controlled trial of inhaled glutathione vs placebo in patients with cystic fibrosis.
Calabrese C, Tosco A, Abete P, Carnovale V, Basile C, Magliocca A, Quattrucci S, De Sanctis S, Alatri F, Mazzarella G, De Pietro L, Turino C, Melillo E, Buonpensiero P, Di Pasqua A, Raia V. Calabrese C, et al. Among authors: tosco a. J Cyst Fibros. 2015 Mar;14(2):203-10. doi: 10.1016/j.jcf.2014.09.014. Epub 2014 Nov 4. J Cyst Fibros. 2015. PMID: 25458463 Free article. Clinical Trial.
Cysteamine re-establishes the clearance of Pseudomonas aeruginosa by macrophages bearing the cystic fibrosis-relevant F508del-CFTR mutation.
Ferrari E, Monzani R, Villella VR, Esposito S, Saluzzo F, Rossin F, D'Eletto M, Tosco A, De Gregorio F, Izzo V, Maiuri MC, Kroemer G, Raia V, Maiuri L. Ferrari E, et al. Among authors: tosco a. Cell Death Dis. 2017 Jan 12;8(1):e2544. doi: 10.1038/cddis.2016.476. Cell Death Dis. 2017. PMID: 28079883 Free PMC article.
May the new suggested lower borderline limit of sweat chloride impact the diagnostic process for cystic fibrosis?
Cirilli N, Braggion C, Mergni G, Polizzi AM, Padoan R, Sirianni S, Seia M, Raia V, Tosco A, Pisi G, Spaggiari C, Quattromano E, Bignamini E, Brandino D, Bella S, Argentini R; ICFS Sweat Test Working Group. Cirilli N, et al. Among authors: tosco a. J Pediatr. 2018 Mar;194:261-262. doi: 10.1016/j.jpeds.2017.11.053. Epub 2018 Jan 17. J Pediatr. 2018. PMID: 29352589 No abstract available.
Mutation-specific therapies and drug repositioning in cystic fibrosis.
Villella VR, Tosco A, Esposito S, Bona G, Raia V, Maiuri L. Villella VR, et al. Among authors: tosco a. Minerva Pediatr. 2019 Jun;71(3):287-296. doi: 10.23736/S0026-4946.19.05506-3. Epub 2019 Feb 13. Minerva Pediatr. 2019. PMID: 30761820 Review.
138 results