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Covalent α-synuclein dimers: chemico-physical and aggregation properties.
Pivato M, De Franceschi G, Tosatto L, Frare E, Kumar D, Aioanei D, Brucale M, Tessari I, Bisaglia M, Samori B, de Laureto PP, Bubacco L. Pivato M, et al. Among authors: tosatto l. PLoS One. 2012;7(12):e50027. doi: 10.1371/journal.pone.0050027. Epub 2012 Dec 13. PLoS One. 2012. PMID: 23272053 Free PMC article.
Dopamine quinones interact with alpha-synuclein to form unstructured adducts.
Bisaglia M, Tosatto L, Munari F, Tessari I, de Laureto PP, Mammi S, Bubacco L. Bisaglia M, et al. Among authors: tosatto l. Biochem Biophys Res Commun. 2010 Apr 2;394(2):424-8. doi: 10.1016/j.bbrc.2010.03.044. Epub 2010 Mar 10. Biochem Biophys Res Commun. 2010. PMID: 20226175
The chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic pathway and reducing α-synuclein cellular toxicity.
Plotegher N, Kumar D, Tessari I, Brucale M, Munari F, Tosatto L, Belluzzi E, Greggio E, Bisaglia M, Capaldi S, Aioanei D, Mammi S, Monaco HL, Samo B, Bubacco L. Plotegher N, et al. Among authors: tosatto l. Hum Mol Genet. 2014 Nov 1;23(21):5615-29. doi: 10.1093/hmg/ddu275. Epub 2014 Jun 3. Hum Mol Genet. 2014. PMID: 24895406
Alpha-synuclein pore forming activity upon membrane association.
Tosatto L, Andrighetti AO, Plotegher N, Antonini V, Tessari I, Ricci L, Bubacco L, Dalla Serra M. Tosatto L, et al. Biochim Biophys Acta. 2012 Nov;1818(11):2876-83. doi: 10.1016/j.bbamem.2012.07.007. Epub 2012 Jul 20. Biochim Biophys Acta. 2012. PMID: 22820150 Free article.
Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading.
Iljina M, Garcia GA, Horrocks MH, Tosatto L, Choi ML, Ganzinger KA, Abramov AY, Gandhi S, Wood NW, Cremades N, Dobson CM, Knowles TP, Klenerman D. Iljina M, et al. Among authors: tosatto l. Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1206-15. doi: 10.1073/pnas.1524128113. Epub 2016 Feb 16. Proc Natl Acad Sci U S A. 2016. PMID: 26884195 Free PMC article.
Quantifying Co-Oligomer Formation by α-Synuclein.
Iljina M, Dear AJ, Garcia GA, De S, Tosatto L, Flagmeier P, Whiten DR, Michaels TCT, Frenkel D, Dobson CM, Knowles TPJ, Klenerman D. Iljina M, et al. Among authors: tosatto l. ACS Nano. 2018 Nov 27;12(11):10855-10866. doi: 10.1021/acsnano.8b03575. Epub 2018 Oct 29. ACS Nano. 2018. PMID: 30371053 Free PMC article.
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity.
Choi ML, Chappard A, Singh BP, Maclachlan C, Rodrigues M, Fedotova EI, Berezhnov AV, De S, Peddie CJ, Athauda D, Virdi GS, Zhang W, Evans JR, Wernick AI, Zanjani ZS, Angelova PR, Esteras N, Vinokurov AY, Morris K, Jeacock K, Tosatto L, Little D, Gissen P, Clarke DJ, Kunath T, Collinson L, Klenerman D, Abramov AY, Horrocks MH, Gandhi S. Choi ML, et al. Among authors: tosatto l. Nat Neurosci. 2022 Sep;25(9):1134-1148. doi: 10.1038/s41593-022-01140-3. Epub 2022 Aug 30. Nat Neurosci. 2022. PMID: 36042314 Free PMC article.
74 results