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Cyclic AMP-binding protein Epac1 acts as a metabolic sensor to promote cardiomyocyte lipotoxicity.
Laudette M, Sainte-Marie Y, Cousin G, Bergonnier D, Belhabib I, Brun S, Formoso K, Laib L, Tortosa F, Bergoglio C, Marcheix B, Borén J, Lairez O, Fauconnier J, Lucas A, Mialet-Perez J, Moro C, Lezoualc'h F. Laudette M, et al. Among authors: tortosa f. Cell Death Dis. 2021 Sep 1;12(9):824. doi: 10.1038/s41419-021-04113-9. Cell Death Dis. 2021. PMID: 34471096 Free PMC article.
Multifunctional Mitochondrial Epac1 Controls Myocardial Cell Death.
Fazal L, Laudette M, Paula-Gomes S, Pons S, Conte C, Tortosa F, Sicard P, Sainte-Marie Y, Bisserier M, Lairez O, Lucas A, Roy J, Ghaleh B, Fauconnier J, Mialet-Perez J, Lezoualc'h F. Fazal L, et al. Among authors: tortosa f. Circ Res. 2017 Feb 17;120(4):645-657. doi: 10.1161/CIRCRESAHA.116.309859. Epub 2017 Jan 17. Circ Res. 2017. PMID: 28096195 Free article.
Mitochondrial 4-HNE derived from MAO-A promotes mitoCa2+ overload in chronic postischemic cardiac remodeling.
Santin Y, Fazal L, Sainte-Marie Y, Sicard P, Maggiorani D, Tortosa F, Yücel YY, Teyssedre L, Rouquette J, Marcellin M, Vindis C, Shih JC, Lairez O, Burlet-Schiltz O, Parini A, Lezoualc'h F, Mialet-Perez J. Santin Y, et al. Among authors: tortosa f. Cell Death Differ. 2020 Jun;27(6):1907-1923. doi: 10.1038/s41418-019-0470-y. Epub 2019 Dec 9. Cell Death Differ. 2020. PMID: 31819159 Free PMC article.
Carabin protects against cardiac hypertrophy by blocking calcineurin, Ras, and Ca2+/calmodulin-dependent protein kinase II signaling.
Bisserier M, Berthouze-Duquesnes M, Breckler M, Tortosa F, Fazal L, de Régibus A, Laurent AC, Varin A, Lucas A, Branchereau M, Marck P, Schickel JN, Deloménie C, Cazorla O, Soulas-Sprauel P, Crozatier B, Morel E, Heymes C, Lezoualc'h F. Bisserier M, et al. Among authors: tortosa f. Circulation. 2015 Jan 27;131(4):390-400; discussion 400. doi: 10.1161/CIRCULATIONAHA.114.010686. Epub 2014 Nov 4. Circulation. 2015. PMID: 25369805
p53-PGC-1α pathway mediates oxidative mitochondrial damage and cardiomyocyte necrosis induced by monoamine oxidase-A upregulation: role in chronic left ventricular dysfunction in mice.
Villeneuve C, Guilbeau-Frugier C, Sicard P, Lairez O, Ordener C, Duparc T, De Paulis D, Couderc B, Spreux-Varoquaux O, Tortosa F, Garnier A, Knauf C, Valet P, Borchi E, Nediani C, Gharib A, Ovize M, Delisle MB, Parini A, Mialet-Perez J. Villeneuve C, et al. Among authors: tortosa f. Antioxid Redox Signal. 2013 Jan 1;18(1):5-18. doi: 10.1089/ars.2011.4373. Epub 2012 Aug 10. Antioxid Redox Signal. 2013. PMID: 22738191 Free PMC article.
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