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GMP Manufacturing and IND-Enabling Studies of a Recombinant Hyperimmune Globulin Targeting SARS-CoV-2.
Mizrahi RA, Lin WY, Gras A, Niedecken AR, Wagner EK, Keating SM, Ikon N, Manickam VA, Asensio MA, Leong J, Medina-Cucurella AV, Benzie E, Carter KP, Chiang Y, Edgar RC, Leong R, Lim YW, Simons JF, Spindler MJ, Stadtmiller K, Wayham N, Büscher D, Terencio JV, Germanio CD, Chamow SM, Olson C, Pino PA, Park JG, Hicks A, Ye C, Garcia-Vilanova A, Martinez-Sobrido L, Torrelles JB, Johnson DS, Adler AS. Mizrahi RA, et al. Among authors: torrelles jb. Pathogens. 2022 Jul 19;11(7):806. doi: 10.3390/pathogens11070806. Pathogens. 2022. PMID: 35890050 Free PMC article.
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice.
Oladunni FS, Park JG, Pino PA, Gonzalez O, Akhter A, Allué-Guardia A, Olmo-Fontánez A, Gautam S, Garcia-Vilanova A, Ye C, Chiem K, Headley C, Dwivedi V, Parodi LM, Alfson KJ, Staples HM, Schami A, Garcia JI, Whigham A, Platt RN 2nd, Gazi M, Martinez J, Chuba C, Earley S, Rodriguez OH, Mdaki SD, Kavelish KN, Escalona R, Hallam CRA, Christie C, Patterson JL, Anderson TJC, Carrion R Jr, Dick EJ Jr, Hall-Ursone S, Schlesinger LS, Alvarez X, Kaushal D, Giavedoni LD, Turner J, Martinez-Sobrido L, Torrelles JB. Oladunni FS, et al. Among authors: torrelles jb. Nat Commun. 2020 Nov 30;11(1):6122. doi: 10.1038/s41467-020-19891-7. Nat Commun. 2020. PMID: 33257679 Free PMC article.
Antiviral activity of oleandrin and a defined extract of Nerium oleander against SARS-CoV-2.
Plante KS, Dwivedi V, Plante JA, Fernandez D, Mirchandani D, Bopp N, Aguilar PV, Park JG, Tamayo PP, Delgado J, Shivanna V, Torrelles JB, Martinez-Sobrido L, Matos R, Weaver SC, Sastry KJ, Newman RA. Plante KS, et al. Among authors: torrelles jb. Biomed Pharmacother. 2021 Jun;138:111457. doi: 10.1016/j.biopha.2021.111457. Epub 2021 Mar 3. Biomed Pharmacother. 2021. PMID: 33721754 Free PMC article.
Contribution of SARS-CoV-2 Accessory Proteins to Viral Pathogenicity in K18 Human ACE2 Transgenic Mice.
Silvas JA, Vasquez DM, Park JG, Chiem K, Allué-Guardia A, Garcia-Vilanova A, Platt RN, Miorin L, Kehrer T, Cupic A, Gonzalez-Reiche AS, Bakel HV, García-Sastre A, Anderson T, Torrelles JB, Ye C, Martinez-Sobrido L. Silvas JA, et al. Among authors: torrelles jb. J Virol. 2021 Aug 10;95(17):e0040221. doi: 10.1128/JVI.00402-21. Epub 2021 Aug 10. J Virol. 2021. PMID: 34133899 Free PMC article.
Immunogenicity and protective efficacy of an intranasal live-attenuated vaccine against SARS-CoV-2.
Park JG, Oladunni FS, Rohaim MA, Whittingham-Dowd J, Tollitt J, Hodges MDJ, Fathallah N, Assas MB, Alhazmi W, Almilaibary A, Iqbal M, Chang P, Escalona R, Shivanna V, Torrelles JB, Worthington JJ, Jackson-Jones LH, Martinez-Sobrido L, Munir M. Park JG, et al. Among authors: torrelles jb. iScience. 2021 Sep 24;24(9):102941. doi: 10.1016/j.isci.2021.102941. Epub 2021 Aug 4. iScience. 2021. PMID: 34368648 Free PMC article.
A Bifluorescent-Based Assay for the Identification of Neutralizing Antibodies against SARS-CoV-2 Variants of Concern In Vitro and In Vivo.
Chiem K, Morales Vasquez D, Silvas JA, Park JG, Piepenbrink MS, Sourimant J, Lin MJ, Greninger AL, Plemper RK, Torrelles JB, Walter MR, de la Torre JC, Kobie JK, Ye C, Martinez-Sobrido L. Chiem K, et al. Among authors: torrelles jb. J Virol. 2021 Oct 27;95(22):e0112621. doi: 10.1128/JVI.01126-21. Epub 2021 Sep 8. J Virol. 2021. PMID: 34495697 Free PMC article.
Analysis of SARS-CoV-2 infection dynamic in vivo using reporter-expressing viruses.
Ye C, Chiem K, Park JG, Silvas JA, Morales Vasquez D, Sourimant J, Lin MJ, Greninger AL, Plemper RK, Torrelles JB, Kobie JJ, Walter MR, de la Torre JC, Martinez-Sobrido L. Ye C, et al. Among authors: torrelles jb. Proc Natl Acad Sci U S A. 2021 Oct 12;118(41):e2111593118. doi: 10.1073/pnas.2111593118. Proc Natl Acad Sci U S A. 2021. PMID: 34561300 Free PMC article.
The K18-Human ACE2 Transgenic Mouse Model Recapitulates Non-severe and Severe COVID-19 in Response to an Infectious Dose of the SARS-CoV-2 Virus.
Dong W, Mead H, Tian L, Park JG, Garcia JI, Jaramillo S, Barr T, Kollath DS, Coyne VK, Stone NE, Jones A, Zhang J, Li A, Wang LS, Milanes-Yearsley M, Torrelles JB, Martinez-Sobrido L, Keim PS, Barker BM, Caligiuri MA, Yu J. Dong W, et al. Among authors: torrelles jb. J Virol. 2022 Jan 12;96(1):e0096421. doi: 10.1128/JVI.00964-21. Epub 2021 Oct 20. J Virol. 2022. PMID: 34668775 Free PMC article.
137 results