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Page 1
Clinical proof of concept for a safe and effective NF-κB-targeting strategy in multiple myeloma.
Tornatore L, Capece D, D'Andrea D, Begalli F, Verzella D, Bennett J, Acton G, Campbell EA, Kelly J, Tarbit M, Adams N, Bannoo S, Leonardi A, Sandomenico A, Raimondo D, Ruvo M, Chambery A, Oblak M, Al-Obaidi MJ, Kaczmarski RS, Gabriel I, Oakervee HE, Kaiser MF, Wechalekar A, Benjamin R, Apperley JF, Auner HW, Franzoso G. Tornatore L, et al. Br J Haematol. 2019 May;185(3):588-592. doi: 10.1111/bjh.15569. Epub 2018 Sep 26. Br J Haematol. 2019. PMID: 30255568 Free article. No abstract available.
Cancer-selective targeting of the NF-κB survival pathway with GADD45β/MKK7 inhibitors.
Tornatore L, Sandomenico A, Raimondo D, Low C, Rocci A, Tralau-Stewart C, Capece D, D'Andrea D, Bua M, Boyle E, van Duin M, Zoppoli P, Jaxa-Chamiec A, Thotakura AK, Dyson J, Walker BA, Leonardi A, Chambery A, Driessen C, Sonneveld P, Morgan G, Palumbo A, Tramontano A, Rahemtulla A, Ruvo M, Franzoso G. Tornatore L, et al. Cancer Cell. 2014 Oct 13;26(4):495-508. doi: 10.1016/j.ccr.2014.07.027. Cancer Cell. 2014. PMID: 25314077 Free PMC article.
NF-κB in the crosshairs: Rethinking an old riddle.
Bennett J, Capece D, Begalli F, Verzella D, D'Andrea D, Tornatore L, Franzoso G. Bennett J, et al. Among authors: tornatore l. Int J Biochem Cell Biol. 2018 Feb;95:108-112. doi: 10.1016/j.biocel.2017.12.020. Epub 2017 Dec 23. Int J Biochem Cell Biol. 2018. PMID: 29277662 Free PMC article. Review.
Turning an old GADDget into a troublemaker.
Capece D, D'Andrea D, Verzella D, Tornatore L, Begalli F, Bennett J, Zazzeroni F, Franzoso G. Capece D, et al. Among authors: tornatore l. Cell Death Differ. 2018 Mar;25(4):642-644. doi: 10.1038/s41418-018-0087-6. Epub 2018 Mar 6. Cell Death Differ. 2018. PMID: 29511335 Free PMC article. Review. No abstract available.
Preclinical toxicology and safety pharmacology of the first-in-class GADD45β/MKK7 inhibitor and clinical candidate, DTP3.
Tornatore L, Capece D, D'Andrea D, Begalli F, Verzella D, Bennett J, Acton G, Campbell EA, Kelly J, Tarbit M, Adams N, Bannoo S, Leonardi A, Sandomenico A, Raimondo D, Ruvo M, Chambery A, Oblak M, Al-Obaidi MJ, Kaczmarski RS, Gabriel I, Oakervee HE, Kaiser MF, Wechalekar A, Benjamin R, Apperley JF, Auner HW, Franzoso G. Tornatore L, et al. Toxicol Rep. 2019 Apr 19;6:369-379. doi: 10.1016/j.toxrep.2019.04.006. eCollection 2019. Toxicol Rep. 2019. PMID: 31080744 Free PMC article.
Probing the interaction interface of the GADD45β/MKK7 and MKK7/DTP3 complexes by chemical cross-linking mass spectrometry.
Rega C, Russo R, Focà A, Sandomenico A, Iaccarino E, Raimondo D, Milanetti E, Tornatore L, Franzoso G, Pedone PV, Ruvo M, Chambery A. Rega C, et al. Among authors: tornatore l. Int J Biol Macromol. 2018 Jul 15;114:114-123. doi: 10.1016/j.ijbiomac.2018.03.090. Epub 2018 Mar 20. Int J Biol Macromol. 2018. PMID: 29572137 Free PMC article.
Cancer: NF-κB regulates energy metabolism.
Moretti M, Bennett J, Tornatore L, Thotakura AK, Franzoso G. Moretti M, et al. Among authors: tornatore l. Int J Biochem Cell Biol. 2012 Dec;44(12):2238-43. doi: 10.1016/j.biocel.2012.08.002. Epub 2012 Aug 10. Int J Biochem Cell Biol. 2012. PMID: 22903018 Review.
23 results