Topp B - Search Results

1

Preclinical QSP Modeling in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape.

Nijsen MJMA, Wu F, Bansal L, Bradshaw-Pierce E, Chan JR, Liederer BM, Mettetal JT, Schroeder P, Schuck E, Tsai A, Xu C, Chimalakonda A, Le K, Penney M, Topp B, Yamada A, Spilker ME. Nijsen MJMA, et al. Among authors: topp b. CPT Pharmacometrics Syst Pharmacol. 2018 Mar;7(3):135-146. doi: 10.1002/psp4.12282. Epub 2018 Feb 1. CPT Pharmacometrics Syst Pharmacol. 2018. PMID: 29349875 Free PMC article. Review.

2

Industrialization of Quantitative Systems Pharmacology.

Topp B, Trujillo ME, Sinha V. Topp B, et al. CPT Pharmacometrics Syst Pharmacol. 2019 Jun;8(6):356-358. doi: 10.1002/psp4.12427. Epub 2019 Jun 6. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 31087476 Free PMC article. No abstract available.

3

Applications of Quantitative Systems Pharmacology in Model-Informed Drug Discovery: Perspective on Impact and Opportunities.

Bradshaw EL, Spilker ME, Zang R, Bansal L, He H, Jones RDO, Le K, Penney M, Schuck E, Topp B, Tsai A, Xu C, Nijsen MJMA, Chan JR. Bradshaw EL, et al. Among authors: topp b. CPT Pharmacometrics Syst Pharmacol. 2019 Nov;8(11):777-791. doi: 10.1002/psp4.12463. Epub 2019 Oct 25. CPT Pharmacometrics Syst Pharmacol. 2019. PMID: 31535440 Free PMC article.

4

Beyond the single average tumor: Understanding IO combinations using a clinical QSP model that incorporates heterogeneity in patient response.

Kumar R, Thiagarajan K, Jagannathan L, Liu L, Mayawala K, de Alwis D, Topp B. Kumar R, et al. Among authors: topp b. CPT Pharmacometrics Syst Pharmacol. 2021 Jul;10(7):684-695. doi: 10.1002/psp4.12637. Epub 2021 Jun 5. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 33938166 Free PMC article.

5

Modulation of intratumoural myeloid cells, the hallmark of the anti-tumour efficacy induced by a triple combination: tumour-associated peptide, TLR-3 ligand and α-PD-1.

Zalba S, Belsúe V, Topp B, de Alwis D, Alvarez M, Trocóniz IF, Berraondo P, Garrido MJ. Zalba S, et al. Among authors: topp b. Br J Cancer. 2021 Mar;124(7):1275-1285. doi: 10.1038/s41416-020-01239-z. Epub 2021 Feb 3. Br J Cancer. 2021. PMID: 33531689 Free PMC article.

6

Lesion-level heterogeneity of radiologic progression in patients treated with pembrolizumab.

Topp BG, Thiagarajan K, De Alwis DP, Snyder A, Hellmann MD. Topp BG, et al. Ann Oncol. 2021 Dec;32(12):1618-1625. doi: 10.1016/j.annonc.2021.09.006. Epub 2021 Sep 17. Ann Oncol. 2021. PMID: 34543717 Free article.

7

Semi-Mechanistic Model for the Antitumor Response of a Combination Cocktail of Immuno-Modulators in Non-Inflamed (Cold) Tumors.

Sancho-Araiz A, Zalba S, Garrido MJ, Berraondo P, Topp B, de Alwis D, Parra-Guillen ZP, Mangas-Sanjuan V, Trocóniz IF. Sancho-Araiz A, et al. Among authors: topp b. Cancers (Basel). 2021 Oct 9;13(20):5049. doi: 10.3390/cancers13205049. Cancers (Basel). 2021. PMID: 34680196 Free PMC article.

8

Incorporating lesion-to-lesion heterogeneity into early oncology decision making.

Kumar R, Qi T, Cao Y, Topp B. Kumar R, et al. Among authors: topp b. Front Immunol. 2023 Jun 7;14:1173546. doi: 10.3389/fimmu.2023.1173546. eCollection 2023. Front Immunol. 2023. PMID: 37350966 Free PMC article. Review.

9

Tumor dynamics in patients with solid tumors treated with pembrolizumab beyond disease progression.

Topp BG, Channavazzala M, Mayawala K, De Alwis DP, Rubin E, Snyder A, Wolchok JD, Ribas A. Topp BG, et al. Cancer Cell. 2023 Sep 11;41(9):1680-1688.e2. doi: 10.1016/j.ccell.2023.08.004. Cancer Cell. 2023. PMID: 37699333 Free article.

10

RECISTv1.1 progression in oncology: Shades of gray.

Topp B, Snyder A, Wolchok J. Topp B, et al. Cancer Cell. 2023 Jun 12;41(6):1003-1005. doi: 10.1016/j.ccell.2023.04.012. Epub 2023 May 11. Cancer Cell. 2023. PMID: 37172579

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