Topchyan P - Search Results

1

Tumor Derived Extracellular Vesicles Drive T Cell Exhaustion in Tumor Microenvironment through Sphingosine Mediated Signaling and Impacting Immunotherapy Outcomes in Ovarian Cancer.

Gupta P, Kadamberi IP, Mittal S, Tsaih SW, George J, Kumar S, Vijayan DK, Geethadevi A, Parashar D, Topchyan P, McAlarnen L, Volkman BF, Cui W, Zhang KYJ, Di Vizio D, Chaluvally-Raghavan P, Pradeep S. Gupta P, et al. Among authors: topchyan p. Adv Sci (Weinh). 2022 May;9(14):e2104452. doi: 10.1002/advs.202104452. Epub 2022 Mar 15. Adv Sci (Weinh). 2022. PMID: 35289120 Free PMC article.

2

Pathogen-Boosted Adoptive Cell Transfer Therapy Induces Endogenous Antitumor Immunity through Antigen Spreading.

Xin G, Khatun A, Topchyan P, Zander R, Volberding PJ, Chen Y, Shen J, Fu C, Jiang A, See WA, Cui W. Xin G, et al. Among authors: topchyan p. Cancer Immunol Res. 2020 Jan;8(1):7-18. doi: 10.1158/2326-6066.CIR-19-0251. Epub 2019 Nov 12. Cancer Immunol Res. 2020. PMID: 31719059 Free PMC article.

3

Potent inhibition of tumour cell proliferation and immunoregulatory function by mitochondria-targeted atovaquone.

Cheng G, Hardy M, Topchyan P, Zander R, Volberding P, Cui W, Kalyanaraman B. Cheng G, et al. Among authors: topchyan p. Sci Rep. 2020 Oct 21;10(1):17872. doi: 10.1038/s41598-020-74808-0. Sci Rep. 2020. PMID: 33087770 Free PMC article.

4

Targeting PIM1-Mediated Metabolism in Myeloid Suppressor Cells to Treat Cancer.

Xin G, Chen Y, Topchyan P, Kasmani MY, Burns R, Volberding PJ, Wu X, Cohn A, Chen Y, Lin CW, Ho PC, Silverstein R, Dwinell MB, Cui W. Xin G, et al. Among authors: topchyan p. Cancer Immunol Res. 2021 Apr;9(4):454-469. doi: 10.1158/2326-6066.CIR-20-0433. Epub 2021 Feb 12. Cancer Immunol Res. 2021. PMID: 33579728 Free PMC article.

5

Harnessing the IL-21-BATF Pathway in the CD8⁺ T Cell Anti-Tumor Response.

Topchyan P, Xin G, Chen Y, Zheng S, Burns R, Shen J, Kasmani MY, Kudek M, Yang N, Cui W. Topchyan P, et al. Cancers (Basel). 2021 Mar 12;13(6):1263. doi: 10.3390/cancers13061263. Cancers (Basel). 2021. PMID: 33809259 Free PMC article.

6

Mitochondria-targeted hydroxyurea inhibits OXPHOS and induces antiproliferative and immunomodulatory effects.

Cheng G, Hardy M, Topchyan P, Zander R, Volberding P, Cui W, Kalyanaraman B. Cheng G, et al. Among authors: topchyan p. iScience. 2021 May 31;24(6):102673. doi: 10.1016/j.isci.2021.102673. eCollection 2021 Jun 25. iScience. 2021. PMID: 34189437 Free PMC article.

7

Single-Cell Transcriptomics Reveals Core Regulatory Programs That Determine the Heterogeneity of Circulating and Tissue-Resident Memory CD8⁺ T Cells.

Chen Y, Shen J, Kasmani MY, Topchyan P, Cui W. Chen Y, et al. Among authors: topchyan p. Cells. 2021 Aug 20;10(8):2143. doi: 10.3390/cells10082143. Cells. 2021. PMID: 34440912 Free PMC article.

8

Tfh-cell-derived interleukin 21 sustains effector CD8⁺ T cell responses during chronic viral infection.

Zander R, Kasmani MY, Chen Y, Topchyan P, Shen J, Zheng S, Burns R, Ingram J, Cui C, Joshi N, Craft J, Zajac A, Cui W. Zander R, et al. Among authors: topchyan p. Immunity. 2022 Mar 8;55(3):475-493.e5. doi: 10.1016/j.immuni.2022.01.018. Epub 2022 Feb 24. Immunity. 2022. PMID: 35216666 Free PMC article.

9

Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection.

Kasmani MY, Zander R, Chung HK, Chen Y, Khatun A, Damo M, Topchyan P, Johnson KE, Levashova D, Burns R, Lorenz UM, Tarakanova VL, Joshi NS, Kaech SM, Cui W. Kasmani MY, et al. Among authors: topchyan p. J Exp Med. 2023 Jan 2;220(1):e20220679. doi: 10.1084/jem.20220679. Epub 2022 Oct 31. J Exp Med. 2023. PMID: 36315049 Free PMC article.

10

Spatial transcriptomics demonstrates the role of CD4 T cells in effector CD8 T cell differentiation during chronic viral infection.

Topchyan P, Zander R, Kasmani MY, Nguyen C, Brown A, Lin S, Burns R, Cui W. Topchyan P, et al. Cell Rep. 2022 Nov 29;41(9):111736. doi: 10.1016/j.celrep.2022.111736. Cell Rep. 2022. PMID: 36450262 Free PMC article.

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